Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 3/20 | 0.42 |
| ▸ | HRH1 | P35367 | 3/20 | 0.42 |
| ▸ | KHK | P50053 | 2/20 | 0.41 |
| ▸ | TGM2 | P21980 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 3/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CCR4 | P51679 | 1/20 | 0.36 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3265551 | 0.87 | HRH2 (0.42) | HRH2HRH1KHKTGM2RORC | |
| SCHEMBL689276 | 0.83 | EPHX2 (0.43) | RORCDHODHMEN1KMT2AKDM4E | |
| SCHEMBL3228839 | 0.83 | EPHX2 (0.43) | RORCDHODHMEN1KMT2AKDM4E | |
| SCHEMBL690229 | 0.83 | EPHX2 (0.43) | RORCDHODHMEN1KMT2AKDM4E | |
| SCHEMBL3267163 | 0.83 | EPHX2 (0.37) | RORCDHODHMEN1KMT2AKDM4E | |
| SCHEMBL3233902 | 0.83 | RORC (0.39) | RORCDHODHMEN1KMT2AKDM4E | |
| SCHEMBL3267550 | 0.83 | MTNR1B (0.43) | RORCDHODHMEN1KMT2AKDM4E | |
| SCHEMBL3220898 | 0.82 | MTNR1B (0.39) | RORCDHODHMEN1KMT2AKDM4E | |
| SCHEMBL692868 | 0.80 | LMNA (0.42) | MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL3264487 | 0.78 | FAAH (0.34) | RORCDHODHMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010026096-A1 | 7-(PIPERAZINE-1-YMETHYL)-1H-INDOLE-2-CARBOXYLIC ACID (PHENYL)-AMIDE DERIVATIVES AND ALLIED COMPOUNDS AS P38 MAP KINASE INHIBITORS FOR THE TREATMENT OF RESPIRATORY DISEASES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-03-11 | — | — | WO | claimed |
| WO-2010026096-A1 | 7-(PIPERAZINE-1-YMETHYL)-1H-INDOLE-2-CARBOXYLIC ACID (PHENYL)-AMIDE DERIVATIVES AND ALLIED COMPOUNDS AS P38 MAP KINASE INHIBITORS FOR THE TREATMENT OF RESPIRATORY DISEASES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-03-11 | — | — | WO | disclosed |