SCHEMBL3266754

SCHEMBL3266754

COC(=O)C(Cc1ccc(OC)cc1)(Cc1ccc(OC)cc1)C(=O)OC

nearest known ligand 0.71

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
PTPRB P23467 9/20 0.71
PTPN1 P18031 2/20 0.54
PTPN2 P17706 1/20 0.54
PTPRA P18433 1/20 0.54
HTT P42858 1/20 0.53
F2RL1 P55085 1/20 0.51
GAA P10253 1/20 0.49
SAE1 Q9UBE0 1/20 0.49
UBA2 Q9UBT2 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
LDHA P00338 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2756353 0.86 PTPRB (0.56) PTPRBHTTF2RL1SMN1; SMN2
SCHEMBL13903099 0.84 PTPRB (0.54) PTPRBHTTF2RL1SAE1UBA2
SCHEMBL5208103 0.83 LDHA (0.55) PTPRBPTPN1HTTF2RL1SAE1
SCHEMBL16381569 0.82 PTPRB (0.59) PTPRBPTPN1PTPN2PTPRAHTT
SCHEMBL16892957 0.81 PTPRB (0.51) PTPRBHTTF2RL1SAE1UBA2
SCHEMBL11175367 0.81 PTPRB (0.69) PTPRBPTPN1PTPN2PTPRA
SCHEMBL17611799 0.81 PTPRB (0.51) PTPRBHTTF2RL1SAE1UBA2
SCHEMBL8039407 0.78 ALDH1A1 (0.50) PTPRBPTPN1HTTF2RL1SMN1; SMN2
SCHEMBL28354143 0.78 PTPRB (0.49) PTPRBHTTF2RL1SAE1UBA2
SCHEMBL12373188 0.77 LMNA (0.51) PTPRBGAASMN1; SMN2LDHA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230285378-A1 Anti-Viral Compounds ABBVIE INC. (US) 2023-09-14 US disclosed
US-20190015402-A1 Anti-Viral Compounds ABBVIE INC. (US) 2019-01-17 US disclosed
US-10039754-B2 Anti-viral compounds ABBVIE INC. (US) 2018-08-07 US disclosed
US-10028937-B2 Anti-viral compounds ABBVIE INC. (US) 2018-07-24 US disclosed
US-20170157105-A1 Anti-Viral Compounds ABBVIE INC. (US) 2017-06-08 US disclosed
US-20170157104-A1 Anti-Viral Compounds ABBVIE INC. (US) 2017-06-08 US disclosed
EP-2678334-B1 ANTI-VIRAL COMPOUNDS ABBVIE BAHAMAS LTD (BS) 2017-03-22 EP disclosed
US-9586978-B2 Anti-viral compounds ABBVIE INC. (US) 2017-03-07 US disclosed
EP-2692346-B1 An antiviral 1-phenyl-2,5-dibenzimidazol-5-yl-pyrrolidine derivative ABBVIE BAHAMAS LTD (BS) 2015-12-02 EP disclosed
US-20150087618-A1 Anti-Viral Compounds ABBVIE INC. (US) 2015-03-26 US disclosed
US-8937150-B2 Anti-viral compounds ABBVIE INC. (US) 2015-01-20 US disclosed
US-8921514-B2 Anti-viral compounds ABBVIE INC. (US) 2014-12-30 US disclosed
EP-2692726-A1 Anti-viral compounds Abbvie Inc. (US) 2014-02-05 EP disclosed
EP-2692346-A1 An antiviral 1-phenyl-2,5-dibenzimidazol-5-yl-pyrrolidine derivative Abbvie Inc. (US) 2014-02-05 EP disclosed
US-20120220562-A1 Anti-Viral Compounds Abbott Labaoratories (US) 2012-08-30 US disclosed
WO-2012116257-A1 ANTI-VIRAL COMPOUNDS ABBVIE INC. (US) 2012-08-30 WO disclosed
WO-2012051361-A1 ANTI-VIRAL COMPOUNDS ABBOTT LABORATORIES (US) 2012-04-19 WO disclosed
US-20120004196-A1 Anti-Viral Compounds Abbott Labaoratories (US) 2012-01-05 US disclosed
US-20110207699-A1 Anti-Viral Compounds Abbott Labaoratories (US) 2011-08-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10028937-B2 Anti-viral compounds HAVCR2, EIF2AK2, MAVS PTPRB 1998/4885PTPN1 2467/4885PTPN2 2115/4885
US-20230285378-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS PTPRB 1998/4885PTPN1 2467/4885PTPN2 2115/4885
US-20120220562-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS PTPRB 1998/4885PTPN1 2467/4885PTPN2 2115/4885
US-20170157105-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS PTPRB 1998/4885PTPN1 2467/4885PTPN2 2115/4885
US-20170157104-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS PTPRB 1998/4885PTPN1 2467/4885PTPN2 2115/4885
US-20150087618-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS PTPRB 1998/4885PTPN1 2467/4885PTPN2 2115/4885
US-20110207699-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS PTPRB 1998/4885PTPN1 2467/4885PTPN2 2115/4885
US-20190015402-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS PTPRB 1998/4885PTPN1 2467/4885PTPN2 2115/4885
US-20120004196-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS PTPRB 1998/4885PTPN1 2467/4885PTPN2 2115/4885
US-10039754-B2 Anti-viral compounds HAVCR2, EIF2AK2, MAVS PTPRB 1998/4885PTPN1 2467/4885PTPN2 2115/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.