SCHEMBL32667657

SCHEMBL32667657

COC(=O)c1cc2cc(O[Si](C)(C)C(C)(C)C)ccc2[nH]1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
XDH P47989 2/20 0.60
PDGFRB P09619 2/20 0.51
PDGFRA P16234 2/20 0.51
KDM4E B2RXH2 5/20 0.51
ALDH1A1 P00352 3/20 0.51
NPC1 O15118 2/20 0.51
RAB9A P51151 2/20 0.51
LMNA P02545 1/20 0.51
HPGD P15428 1/20 0.51
HTT P42858 1/20 0.51
L3MBTL1 Q9Y468 1/20 0.51
FLT3 P36888 5/20 0.48
KMT2A Q03164 2/20 0.46
GAA P10253 1/20 0.46
MEN1 O00255 1/20 0.45
CYP1A2 P05177 1/20 0.45
CYP3A4 P08684 1/20 0.45
CYP2C9 P11712 1/20 0.45
TSHR P16473 1/20 0.45
HDAC6 Q9UBN7 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31207819 1.00 XDH (0.60) XDHPDGFRBPDGFRAKDM4EALDH1A1
SCHEMBL3017521 0.90 XDH (0.47) XDHPDGFRBPDGFRAKDM4EALDH1A1
SCHEMBL829044 0.86 KDM4E (0.67) PDGFRBPDGFRAKDM4EALDH1A1NPC1
SCHEMBL31361409 0.81 PDGFRB (0.77) XDHPDGFRBPDGFRAKDM4EALDH1A1
SCHEMBL1104006 0.81 PDGFRB (0.77) XDHPDGFRBPDGFRAKDM4EALDH1A1
SCHEMBL6518676 0.79 KDM4E (0.71) XDHPDGFRBPDGFRAKDM4EALDH1A1
SCHEMBL22077708 0.77 MTNR1A (0.49) XDHPDGFRBPDGFRAKDM4EALDH1A1
SCHEMBL8680473 0.77 CA1 (0.52) XDHKDM4EHTTCYP3A4CA12
SCHEMBL4192383 0.76 EIF4A3 (0.49) PDGFRBPDGFRAKDM4EALDH1A1NPC1
SCHEMBL2083218 0.75 FLT3 (0.65) XDHPDGFRBPDGFRAKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260028334-A1 N-(3-(BENZO[B]THIOPHENE-2-CARBOXAMIDO)-PHENYL)-2,3-DIHYDROBENZO[B][1,4]DIOXINE-6-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS LACTATE/ATP PRODUCTION INHIBITORS FOR THE TREATMENT OF CANCER WMT AG (DE) 2026-01-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260028334-A1 N-(3-(BENZO[B]THIOPHENE-2-CARBOXAMIDO)-PHENYL)-2,3-DIHYDROBENZO[B][1,4]DIOXINE-6-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS LACTATE/ATP PRODUCTION INHIBITORS FOR THE TREATMENT OF CANCER LDHA, LDHB, SLC6A1 XDH 358/4885PDGFRB 3223/4885PDGFRA 3512/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.