Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 11/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | YAP1 | P46937 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3267959 | 0.82 | MMP13 (0.49) | MEN1KMT2AGPR119JAK2JAK1 | |
| SCHEMBL3268175 | 0.81 | GPR119 (0.48) | MEN1KMT2AGPR119JAK2JAK1 | |
| SCHEMBL2448063 | 0.80 | FAAH (0.63) | MEN1KMT2AGPR119FAAHHPGDS | |
| SCHEMBL5766363 | 0.79 | FAAH (0.50) | GPR119FAAHHPGDS | |
| SCHEMBL3269387 | 0.79 | CYP11B2 (0.46) | MEN1KMT2AGPR119 | |
| SCHEMBL3268837 | 0.79 | ACHE (0.44) | MEN1KMT2AGPR119JAK2JAK1 | |
| SCHEMBL23360130 | 0.78 | MEN1 (0.48) | MEN1KMT2AGPR119 | |
| SCHEMBL23360302 | 0.78 | MEN1 (0.50) | MEN1KMT2AGPR119HPGDS | |
| SCHEMBL3267607 | 0.78 | GPR119 (0.44) | GPR119 | |
| SCHEMBL3267795 | 0.77 | SLC6A2 (0.64) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1735302-B1 | 4-AMINO-PIPERIDINE DERIVATIVES AS MONOAMINE UPTAKE INHIBITORS | LILLY CO ELI (US) | 2010-06-16 | — | — | EP | disclosed |
| US-7521462-B2 | 4-Amino-piperidine derivatives as monoamine uptake inhibitors | ELI LILLY AND COMPANY (US) | 2009-04-21 | — | — | US | disclosed |
| US-20070093526-A1 | 4-Amino-piperidine derivatives as monoamine uptake inhibitors | ELI LILLY AND COMPANY (US) | 2007-04-26 | — | — | US | disclosed |
| EP-1735302-A1 | 4-AMINO-PIPERIDINE DERIVATIVES AS MONOAMINE UPTAKE INHIBITORS | ELI LILLY AND COMPANY (US) | 2006-12-27 | — | — | EP | disclosed |
| WO-2005092885-A1 | 4-AMINO-PIPERIDINE DERIVATIVES AS MONOAMINE UPTAKE INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-10-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070093526-A1 | 4-Amino-piperidine derivatives as monoamine uptake inhibitors | SLC18A2, SLC6A2, SLC6A3 | MEN1 2754/4885KMT2A 1693/4885GPR119 223/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.