3,5-Dihydroxybenzoic Acid

3,5-Dihydroxybenzoic Acid

SCHEMBL32679272

O.O=C(O)c1cc(O)cc(O)c1

nearest known ligand 0.94

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of 3,5-Dihydroxybenzoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DPP4 known ✓ P27487 1/20 0.55
MEN1 known ✓ O00255 1/20 0.45
EGFR known ✓ P00533 1/20 0.45
CA12 O43570 5/20 0.94
CA1 P00915 5/20 0.94
CA2 P00918 5/20 0.94
CA9 Q16790 5/20 0.94
CA7 P43166 4/20 0.94
CA14 Q9ULX7 4/20 0.94
HCAR1 Q9BXC0 3/20 0.65
CA5A P35218 3/20 0.55
CA6 P23280 3/20 0.55
CA3 P07451 2/20 0.55
CA4 P22748 2/20 0.55
CA5B Q9Y2D0 2/20 0.55
ALDH1A1 P00352 2/20 0.55
MAPT P10636 2/20 0.55
HPGD P15428 2/20 0.55
MAPK1 P28482 2/20 0.55
TDP1 Q9NUW8 2/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
3,5-Dihydroxybenzoic Acid SCHEMBL28106 0.97 CA12 (1.00) CA12CA1CA2CA9CA7
3,5-Dihydroxybenzoic Acid SCHEMBL618767 0.97 CA12 (1.00) CA12CA1CA2CA9CA7
3,5-Dihydroxybenzoic Acid SCHEMBL10936753 0.94 CA12 (0.94) CA12CA1CA2CA9CA7
3,5-Dihydroxybenzoic Acid SCHEMBL1151737 0.94 CA12 (0.94) CA12CA1CA2CA9CA7
3,5-Dihydroxybenzoic Acid SCHEMBL9693437 0.94 CA12 (0.94) CA12CA1CA2CA9CA7
3,5-Dihydroxybenzoic Acid SCHEMBL5695849 0.94 CA12 (0.94) CA12CA1CA2CA9CA7
SCHEMBL139644 0.91 CA12 (0.88) CA12CA1CA2CA9CA7
Phloroglucinol SCHEMBL21465836 0.91 CA12 (0.88) CA12CA1CA2CA9CA7
SCHEMBL9178343 0.88 CA12 (0.83) CA12CA1CA2CA9CA7
Methane SCHEMBL6131088 0.88 CA12 (0.83) CA12CA1CA2CA9CA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-121652109-A Aripiprazole-3, 5-dihydroxybenzoic acid-hydrate crystal form and preparation method thereof 鲁南制药集团股份有限公司 2026-03-13 CN disclosed
CN-121652109-A Aripiprazole-3, 5-dihydroxybenzoic acid-hydrate crystal form and preparation method thereof 鲁南制药集团股份有限公司 2026-03-13 CN disclosed
CN-121574093-A Aripiprazole-2, 3-dihydroxybenzoic acid-hydrate crystal form and preparation method thereof 鲁南制药集团股份有限公司 2026-02-27 CN disclosed