SCHEMBL32688052

SCHEMBL32688052

COC(=O)Cc1cccc(CSc2[nH]c(=O)nc(-c3ccccc3)c2C#N)c1

nearest known ligand 0.56

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 6/20 0.56
▸ POLB P06746 6/20 0.56
▸ KMT2A Q03164 6/20 0.56
▸ ACMSD Q8TDX5 9/20 0.52
▸ TNF P01375 2/20 0.47
▸ NOD2 Q9HC29 2/20 0.47
▸ NOD1 Q9Y239 2/20 0.47
▸ PLA2G1B P04054 1/20 0.44
▸ ATG4B Q9Y4P1 1/20 0.44
▸ RXFP1 Q9HBX9 2/20 0.43
▸ ALDH1A1 P00352 2/20 0.43
▸ BRD4 O60885 1/20 0.43
▸ LMNA P02545 1/20 0.43
▸ MAPT P10636 1/20 0.43
▸ HPGD P15428 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL32688017 0.89 ACMSD (0.56) MEN1POLBKMT2AACMSDTNF
SCHEMBL32688032 0.87 MEN1 (0.74) MEN1POLBKMT2AACMSDTNF
SCHEMBL32688120 0.84 ACMSD (0.72) MEN1POLBKMT2AACMSDTNF
SCHEMBL32688381 0.79 MEN1 (0.49) MEN1POLBKMT2AACMSDTNF
SCHEMBL32688012 0.78 ACMSD (0.49) MEN1POLBKMT2AACMSDALDH1A1
SCHEMBL32688164 0.76 KMT2A (0.47) MEN1POLBKMT2AACMSDALDH1A1
SCHEMBL32688373 0.75 RXFP1 (0.54) MEN1POLBKMT2ARXFP1ALDH1A1
SCHEMBL32688248 0.75 ALDH1A1 (0.55) MEN1POLBKMT2AACMSDRXFP1
SCHEMBL23852913 0.72 ACMSD (0.49) MEN1POLBKMT2AACMSDTNF
SCHEMBL20339582 0.70 KMT2A (0.64) MEN1POLBKMT2AACMSDALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260078105-A1 Novel Aminocarboxymuconate Semialdehyde Decarboxylase Inhibitors ORSOBIO INC (US) 2026-03-19 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260078105-A1 Novel Aminocarboxymuconate Semialdehyde Decarboxylase Inhibitors CPT1B, CBR1, MUSK MEN1 4353/4885POLB 508/4885KMT2A 3400/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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