Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 4/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 6/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.35 |
| ▸ | MST1R | Q04912 | 1/20 | 0.35 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.35 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1463479 | 0.87 | IDO1 (0.57) | IDO1ALDH1A1CYP3A4TSHRMAPK1 | |
| SCHEMBL13404775 | 0.86 | JAK2 (0.41) | MAP4K4BACE1JAK2FGFR1GSK3B | |
| SCHEMBL3274060 | 0.85 | IKBKB (0.35) | IDO1MAP4K4MKNK1MKNK2NTRK1 | |
| SCHEMBL3583617 | 0.85 | SMN1; SMN2 (0.38) | IDO1MAP4K4ALDH1A1CYP3A4TSHR | |
| SCHEMBL3329979 | 0.81 | KIF11 (0.41) | MAP4K4MKNK1MKNK2 | |
| SCHEMBL4025859 | 0.80 | MKNK1 (0.44) | MAP4K4MKNK1MKNK2IKBKB | |
| SCHEMBL3328060 | 0.78 | SCN5A (0.38) | GSK3BKCNH2 | |
| SCHEMBL1308358 | 0.78 | IDO1 (0.41) | IDO1FLT3ALDH1A1CYP3A4TSHR | |
| SCHEMBL3327827 | 0.77 | KCNH2 (0.44) | JAK2ALDH1A1KCNH2IKBKB | |
| SCHEMBL491311 | 0.77 | AHR (0.41) | MAP4K4MKNK1MKNK2ALPLMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155700-B1 | BETA-KETO-AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS | NEUROSEARCH AS (DK) | 2010-10-06 | — | — | EP | disclosed |
| US-20100144809-A1 | NOVEL BENZAMIDINE DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATORS | NEURO SEARCH A/S (DK) | 2010-06-10 | — | — | US | disclosed |
| US-20100137381-A1 | ACETAMIDE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2010-06-03 | — | — | US | disclosed |
| US-20100137387-A1 | BETA-KETO-AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2010-06-03 | — | — | US | disclosed |
| US-20100137387-A1 | BETA-KETO-AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2010-06-03 | — | — | US | disclosed |
| US-20100137381-A1 | ACETAMIDE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2010-06-03 | — | — | US | disclosed |
| US-20100137381-A1 | ACETAMIDE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2010-06-03 | — | — | US | disclosed |
| US-20100137387-A1 | BETA-KETO-AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2010-06-03 | — | — | US | disclosed |
| US-20100087496-A1 | NOVEL CINNAMIC AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2010-04-08 | — | — | US | disclosed |
| US-20100087496-A1 | NOVEL CINNAMIC AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2010-04-08 | — | — | US | disclosed |
| WO-2008135447-A1 | ACETAMIDE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2008-11-13 | — | — | WO | disclosed |
| WO-2008135447-A1 | ACETAMIDE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2008-11-13 | — | — | WO | disclosed |
| WO-2008135448-A1 | BETA-KETO-AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2008-11-13 | — | — | WO | disclosed |
| WO-2008135448-A1 | BETA-KETO-AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2008-11-13 | — | — | WO | disclosed |
| WO-2008135591-A1 | NOVEL BENZAMIDINE DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2008-11-13 | — | — | WO | disclosed |
| EP-1638948-B1 | DIPHENYLUREA DERIVATIVES AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS | NEUROSEARCH AS (DK) | 2008-10-15 | — | — | EP | disclosed |
| WO-2008074755-A2 | NOVEL CINNAMIC AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2008-06-26 | — | — | WO | disclosed |
| WO-2008074755-A2 | NOVEL CINNAMIC AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2008-06-26 | — | — | WO | disclosed |
| US-20070293553-A1 | Diphenylurea Derivatives Useful As Potassium Channel Activators | NEUROSEARCH A/S (DK) | 2007-12-20 | — | — | US | disclosed |
| US-20060178413-A1 | Diphenylurea derivatives and their use as chloride channel blockers | NEUSEARCH A/S (DK) | 2006-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070293553-A1 | Diphenylurea Derivatives Useful As Potassium Channel Activators | KCNJ2, KCNH2, KCNH3 | IDO1 2784/4885MAP4K4 503/4885MKNK1 2495/4885 |
| US-20100137387-A1 | BETA-KETO-AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS | KCNAB1, KCNJ2, KCNN3 | IDO1 4173/4885MAP4K4 598/4885MKNK1 409/4885 |
| US-20100087496-A1 | NOVEL CINNAMIC AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS | TRPV1, TRPA1, TRPM8 | IDO1 4497/4885MAP4K4 1421/4885MKNK1 2876/4885 |
| US-20100144809-A1 | NOVEL BENZAMIDINE DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATORS | KCNB2, KCNN1, KCNB1 | IDO1 1114/4885MAP4K4 479/4885MKNK1 1480/4885 |
| US-20100137381-A1 | ACETAMIDE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS | KCNJ2, KCNJ1, KCNN2 | IDO1 4391/4885MAP4K4 413/4885MKNK1 720/4885 |
| US-20060178413-A1 | Diphenylurea derivatives and their use as chloride channel blockers | CLIC1, CLIC4, CLCN2 | IDO1 3388/4885MAP4K4 4089/4885MKNK1 4301/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.