Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.49 |
| ▸ | GAA | P10253 | 4/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 6/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | PRKACA | P17612 | 4/20 | 0.42 |
| ▸ | PRKACG | P22612 | 4/20 | 0.42 |
| ▸ | PRKACB | P22694 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5072719 | 0.88 | TDP1 (0.48) | ALDH1A1KDM4EGAATDP1CYP1A2 | |
| SCHEMBL31037588 | 0.84 | CYP3A4 (0.46) | MCL1ALDH1A1KDM4ETDP1CYP1A2 | |
| SCHEMBL4168666 | 0.84 | KDM4E (0.55) | ALDH1A1KDM4EGAAHPGDPRKACA | |
| SCHEMBL164458 | 0.84 | TSHR (0.52) | ALDH1A1KDM4EGAATDP1CYP1A2 | |
| SCHEMBL29462390 | 0.84 | TSHR (0.52) | ALDH1A1KDM4EGAATDP1CYP1A2 | |
| SCHEMBL5302056 | 0.82 | MCL1 (0.50) | MCL1ALDH1A1KDM4EGAATDP1 | |
| SCHEMBL4182780 | 0.82 | KDM4E (0.54) | ALDH1A1KDM4EGAAHPGDPRKACA | |
| SCHEMBL3574934 | 0.81 | CYP11B1 (0.50) | ALDH1A1KDM4ECYP1A2CYP2C19CYP2C9 | |
| SCHEMBL3583094 | 0.81 | AR (0.53) | ALDH1A1KDM4ETDP1CYP1A2HPGD | |
| SCHEMBL5302293 | 0.79 | AAK1 (0.53) | CYP3A4MAPTPRKACAPRKACGPRKACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155700-B1 | BETA-KETO-AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS | NEUROSEARCH AS (DK) | 2010-10-06 | — | — | EP | disclosed |
| US-20100144809-A1 | NOVEL BENZAMIDINE DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATORS | NEURO SEARCH A/S (DK) | 2010-06-10 | — | — | US | disclosed |
| US-20100137381-A1 | ACETAMIDE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2010-06-03 | — | — | US | disclosed |
| US-20100137387-A1 | BETA-KETO-AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2010-06-03 | — | — | US | disclosed |
| US-20100137381-A1 | ACETAMIDE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2010-06-03 | — | — | US | disclosed |
| US-20100137381-A1 | ACETAMIDE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2010-06-03 | — | — | US | disclosed |
| US-20100137387-A1 | BETA-KETO-AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2010-06-03 | — | — | US | disclosed |
| US-20100137387-A1 | BETA-KETO-AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2010-06-03 | — | — | US | disclosed |
| US-20100087496-A1 | NOVEL CINNAMIC AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2010-04-08 | — | — | US | disclosed |
| US-20100087496-A1 | NOVEL CINNAMIC AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2010-04-08 | — | — | US | disclosed |
| WO-2008135447-A1 | ACETAMIDE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2008-11-13 | — | — | WO | disclosed |
| EP-1638948-B1 | DIPHENYLUREA DERIVATIVES AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS | NEUROSEARCH AS (DK) | 2008-10-15 | — | — | EP | disclosed |
| WO-2008074755-A2 | NOVEL CINNAMIC AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2008-06-26 | — | — | WO | disclosed |
| WO-2008074755-A2 | NOVEL CINNAMIC AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2008-06-26 | — | — | WO | disclosed |
| US-20070293553-A1 | Diphenylurea Derivatives Useful As Potassium Channel Activators | NEUROSEARCH A/S (DK) | 2007-12-20 | — | — | US | disclosed |
| EP-1827411-A2 | DIPHENYLUREA DERIVATIVES USEFUL AS POTASSIUM CHANNEL ACTIVATORS | NEUROSEARCH A/S (DK) | 2007-09-05 | — | — | EP | disclosed |
| US-20060178413-A1 | Diphenylurea derivatives and their use as chloride channel blockers | NEUSEARCH A/S (DK) | 2006-08-10 | — | — | US | disclosed |
| WO-2006064015-A2 | DIPHENYLUREA DERIVATIVES USEFUL AS POTASSIUM CHANNEL ACTIVATORS | NEUROSEARCH A/S (DK) | 2006-06-22 | — | — | WO | disclosed |
| EP-1638948-A1 | DIPHENYLUREA DERIVATIVES AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS | NEUROSEARCH A/S (DK) | 2006-03-29 | — | — | EP | disclosed |
| WO-2004111017-A1 | DIPHENYLUREA DERIVATIVES AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS | NEUROSEARCH A/S (DK) | 2004-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070293553-A1 | Diphenylurea Derivatives Useful As Potassium Channel Activators | KCNJ2, KCNH2, KCNH3 | MCL1 1786/4885ALDH1A1 418/4885KDM4E 604/4885 |
| US-20100137387-A1 | BETA-KETO-AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS | KCNAB1, KCNJ2, KCNN3 | MCL1 3603/4885ALDH1A1 3067/4885KDM4E 867/4885 |
| US-20100087496-A1 | NOVEL CINNAMIC AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS | TRPV1, TRPA1, TRPM8 | MCL1 4134/4885ALDH1A1 1865/4885KDM4E 2144/4885 |
| US-20100144809-A1 | NOVEL BENZAMIDINE DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATORS | KCNB2, KCNN1, KCNB1 | MCL1 1917/4885ALDH1A1 1776/4885KDM4E 1330/4885 |
| US-20100137381-A1 | ACETAMIDE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS | KCNJ2, KCNJ1, KCNN2 | MCL1 2918/4885ALDH1A1 1272/4885KDM4E 1559/4885 |
| US-20060178413-A1 | Diphenylurea derivatives and their use as chloride channel blockers | CLIC1, CLIC4, CLCN2 | MCL1 1144/4885ALDH1A1 1167/4885KDM4E 2482/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.