SCHEMBL327485

SCHEMBL327485

CCOC(C)C(=O)ON1C(=O)CCC1=O

nearest known ligand 0.35

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.35
KMT2A Q03164 5/20 0.32
MEN1 O00255 4/20 0.32
LMNA P02545 2/20 0.32
RAB9A P51151 1/20 0.32
MGLL Q99685 2/20 0.31
ATM Q13315 1/20 0.31
KDM4E B2RXH2 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12418999 0.83 MGLL (0.33) KMT2AMEN1LMNAMGLL
SCHEMBL8721919 0.82 ALDH1A1 (0.33) ALDH1A1KMT2AMEN1LMNARAB9A
SCHEMBL9314823 0.82 ALDH1A1 (0.33) ALDH1A1KMT2AMEN1LMNARAB9A
SCHEMBL14310541 0.82 NAAA (0.37) ALDH1A1KMT2ALMNARAB9A
SCHEMBL28668764 0.81 GSK3A (0.35) ALDH1A1
SCHEMBL277826 0.80 MGLL (0.33) KMT2AMGLLATM
SCHEMBL261924 0.79 MGLL (0.35) ALDH1A1KMT2AMEN1LMNARAB9A
SCHEMBL16133577 0.79 MGLL (0.35) ALDH1A1KMT2AMEN1LMNARAB9A
SCHEMBL14753540 0.79
SCHEMBL11955590 0.79 TSHR (0.32) KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180207286-A1 CONJUGATES OF A CHOLINESTERASE MOIETY AND A POLYMER NEKTAR THERAPEUTICS 2018-07-26 US disclosed
US-20180085468-A1 CONJUGATES OF AN IL-2 MOIETY AND A POLYMER NEKTAR THERAPEUTICS 2018-03-29 US disclosed
US-9763995-B2 Polymer conjugates of protegrin peptides NEKTAR THERAPEUTICS (US) 2017-09-19 US disclosed
US-20170196975-A1 CONJUGATES OF AN ANTI-TNF-ALPHA ANTIBODY NEKTAR THERAPEUTICS 2017-07-13 US disclosed
US-9636412-B2 Conjugates of an anti-TNF-alpha antibody NEKTAR THERAPEUTICS (US) 2017-05-02 US disclosed
US-20170035896-A1 POLYMER FACTOR IX MOIETY CONJUGATES NEKTAR THERAPEUTICS 2017-02-09 US disclosed
US-20160158311-A1 POLYMER CONJUGATES OF PROTEGRIN PEPTIDES NEKTAR THERAPEUTICS 2016-06-09 US disclosed
US-9347054-B2 Polymer factor IX moiety conjugates NEKTAR THERAPEUTICS (US) 2016-05-24 US disclosed
US-20160030587-A1 CONJUGATES OF AN ANTI-TNF-ALPHA ANTIBODY NEKTAR THERAPEUTICS 2016-02-04 US disclosed
US-9101670-B2 Conjugates of an anti-TNF-α antibody NEKTAR THERAPEUTICS (US) 2015-08-11 US disclosed
US-20100130684-A1 POLYMER FACTOR IX MOIETY CONJUGATES NEKTAR THERAPEUTICS (US) 2010-05-27 US disclosed
US-20100125049-A1 POLYMER FACTOR VIII MOIETY CONJUGATES NEKTAR THERAPEUTICS (US) 2010-05-20 US disclosed
US-20100120689-A1 POLYMER FACTOR VIII MOIETY CONJUGATES NEKTAR THERAPEUTICS (US) 2010-05-13 US disclosed
US-20100120982-A1 POLYMER-FACTOR IX MOIETY CONJUGATES NEKTAR THERAPEUTICS (US) 2010-05-13 US disclosed
US-7714114-B2 Conjugates of an EPO moiety and a polymer NEKTAR THERAPEUTICS (US) 2010-05-11 US disclosed
US-20100021481-A1 CONJUGATES OF AN ANTI-TNF-ALPHA ANTIBODY NEKTAR THERAPEUTICS (US) 2010-01-28 US disclosed
US-20090280550-A1 Polymer-Factor IX Moiety Conjugates NEKTAR THERAPEUTICS AL, CORPORATION (US) 2009-11-12 US disclosed
US-7579444-B2 Polymer-factor IX moiety conjugates NEKTAR THERAPEUTICS AL, CORPORATION (US) 2009-08-25 US disclosed
US-20090041714-A1 Binding element comprising polyethylene glycol and antihemophilic factor for use in treatment of hemophilia NEKTAR THERAPEUTICS AL, CORPORATION (US) 2009-02-12 US disclosed
US-20080058504-A1 Water soluble polyoxyethylene glylcol polyvinylpyrrolidone, polyvinyl alcohol, polyoxazoline, and/or polyacryloylmorpholine, conjugated to antihemophilic factor NEKTAR THERAPEUTICS 2008-03-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090041714-A1 Binding element comprising polyethylene glycol and antihemophilic factor for use in treatment of hemophilia F13B, F8, F13A1 ALDH1A1 3597/4885KMT2A 1613/4885MEN1 3764/4885
US-20100120689-A1 POLYMER FACTOR VIII MOIETY CONJUGATES F8, F9, F13B ALDH1A1 2770/4885KMT2A 1159/4885MEN1 865/4885
US-20170035896-A1 POLYMER FACTOR IX MOIETY CONJUGATES F9, F13A1, F8 ALDH1A1 3118/4885KMT2A 2002/4885MEN1 844/4885
US-20100120982-A1 POLYMER-FACTOR IX MOIETY CONJUGATES F9, F13A1, F13B ALDH1A1 2876/4885KMT2A 2142/4885MEN1 778/4885
US-20100021481-A1 CONJUGATES OF AN ANTI-TNF-ALPHA ANTIBODY TNF, TNFRSF1A, TNFRSF9 ALDH1A1 2494/4885KMT2A 4160/4885MEN1 1777/4885
US-20100125049-A1 POLYMER FACTOR VIII MOIETY CONJUGATES F8, F9, F13B ALDH1A1 2770/4885KMT2A 1159/4885MEN1 865/4885
US-20170196975-A1 CONJUGATES OF AN ANTI-TNF-ALPHA ANTIBODY TNF, TNFRSF1A, TNFRSF9 ALDH1A1 2449/4885KMT2A 4093/4885MEN1 1731/4885
US-20100130684-A1 POLYMER FACTOR IX MOIETY CONJUGATES F9, F13A1, F8 ALDH1A1 3118/4885KMT2A 2002/4885MEN1 844/4885
US-20160030587-A1 CONJUGATES OF AN ANTI-TNF-ALPHA ANTIBODY TNF, TNFRSF1A, TNFRSF9 ALDH1A1 2494/4885KMT2A 4160/4885MEN1 1777/4885
US-20160158311-A1 POLYMER CONJUGATES OF PROTEGRIN PEPTIDES PSMG3, PSMB11, UBQLN1 ALDH1A1 4834/4885KMT2A 3816/4885MEN1 1753/4885
US-20180085468-A1 CONJUGATES OF AN IL-2 MOIETY AND A POLYMER IL2, IL2RA, ILF2 ALDH1A1 3489/4885KMT2A 797/4885MEN1 3695/4885
US-20180207286-A1 CONJUGATES OF A CHOLINESTERASE MOIETY AND A POLYMER BCHE, ACHE, DNPEP ALDH1A1 817/4885KMT2A 896/4885MEN1 1284/4885
US-20080058504-A1 Water soluble polyoxyethylene glylcol polyvinylpyrrolidone, polyvinyl alcohol, polyoxazoline, and/or polyacryloylmorpholine, conjugated to antihemophilic factor F8, F13A1, F13B ALDH1A1 2393/4885KMT2A 1218/4885MEN1 2140/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.