Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PARP15 | Q460N3 | 4/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 2/20 | 0.37 |
| ▸ | DAO | P14920 | 2/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7070839 | 0.76 | KDM4E (0.50) | KDM4EHSD17B10PARP15PARP10BRAF | |
| SCHEMBL3277310 | 0.76 | HSD17B10 (0.46) | KDM4EHSD17B10PARP15PARP10ALDH1A1 | |
| SCHEMBL438637 | 0.72 | AR (0.47) | KDM4EHSD17B10PARP15PARP10ALDH1A1 | |
| SCHEMBL7072330 | 0.72 | BRAF (0.58) | KDM4EHSD17B10ALDH1A1BRAFPIK3CD | |
| SCHEMBL8057185 | 0.72 | CA12 (0.44) | KDM4EHSD17B10PARP15PARP10ALDH1A1 | |
| SCHEMBL20882056 | 0.72 | ROCK2 (0.50) | — | |
| SCHEMBL13875105 | 0.72 | ALDH1A1 (0.53) | KDM4EALDH1A1CCNE2CDK4CCND1 | |
| SCHEMBL28309629 | 0.69 | IP6K1 (0.57) | — | |
| SCHEMBL3069941 | 0.69 | PIK3CD (0.47) | KDM4EHSD17B10PARP15PARP10DAO | |
| SCHEMBL17142230 | 0.69 | KDM4E (0.43) | KDM4EHSD17B10PARP15PARP10BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719151-A | PHTHALAZINEDIONE COMPOUND; POLYMERASE INHIBITOR | SHALL SYDNEY (GB) | 1998-02-17 | — | — | US | disclosed |