Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2523863 | 0.92 | KDM4E (0.62) | ALDH1A1MEN1KMT2AKDM4ECYP1A2 | |
| SCHEMBL537958 | 0.90 | KDM4E (0.69) | ALDH1A1MEN1KMT2AKDM4ECYP1A2 | |
| Magnesium SCHEMBL29732237 | 0.88 | KDM4E (0.68) | ALDH1A1MEN1KMT2AKDM4ECYP1A2 | |
| SCHEMBL25835 | 0.81 | ALDH1A1 (0.60) | ALDH1A1MEN1KMT2AKDM4ECYP1A2 | |
| SCHEMBL4447238 | 0.76 | KDM4E (0.68) | ALDH1A1MEN1KMT2AKDM4ECYP1A2 | |
| SCHEMBL8651089 | 0.76 | KDM4E (0.68) | ALDH1A1MEN1KMT2AKDM4ECYP1A2 | |
| SCHEMBL18000055 | 0.76 | KDM4E (0.68) | ALDH1A1MEN1KMT2AKDM4ECYP1A2 | |
| SCHEMBL11690553 | 0.76 | LMNA (0.61) | ALDH1A1MEN1KMT2AKDM4ECYP1A2 | |
| SCHEMBL28880300 | 0.75 | TSHR (0.81) | ALDH1A1MEN1KMT2AKDM4ETSHR | |
| SCHEMBL10595695 | 0.75 | GAA (0.77) | ALDH1A1MEN1KMT2AKDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100086495-A1 | COMPOSITIONS AND METHODS FOR ENHANCING TRANSMUCOSAL DELIVERY | DERMA-YOUNG LTD. (IL) | 2010-04-08 | — | — | US | claimed |
| WO-2014024193-A1 | COMPOSITIONS AND METHODS FOR RAPID TRANSMUCOSAL DELIVERY OF PHARMACEUTICAL INGREDIENTS | PRODEL PHARMA LTD. (IL) | 2014-02-13 | — | — | WO | disclosed |
| US-20100086495-A1 | COMPOSITIONS AND METHODS FOR ENHANCING TRANSMUCOSAL DELIVERY | DERMA-YOUNG LTD. (IL) | 2010-04-08 | — | — | US | disclosed |
| EP-2114384-A2 | COMPOSITIONS AND METHODS FOR ENHANCING TRANSMUCOSAL DELIVERY | Derma-Young Ltd. (IL) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008099397-A2 | COMPOSITIONS AND METHODS FOR ENHANCING TRANSMUCOSAL DELIVERY | DERMA-YOUNG LTD. (IL) | 2008-08-21 | — | — | WO | disclosed |