SCHEMBL328219

SCHEMBL328219

CNC(=O)c1ccc(C)cc1C

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 3/20 0.56
KMT2A Q03164 2/20 0.56
HTT P42858 1/20 0.56
FLT1 P17948 1/20 0.51
FLT4 P35916 1/20 0.51
KDR P35968 1/20 0.51
RAB9A P51151 4/20 0.50
NPC1 O15118 3/20 0.50
TAS1R3 Q7RTX0 1/20 0.50
TAS1R1 Q7RTX1 1/20 0.50
TAS1R2 Q8TE23 1/20 0.50
KDM4E B2RXH2 2/20 0.49
ALDH1A1 P00352 2/20 0.49
GLA P06280 1/20 0.49
MAPT P10636 1/20 0.49
MCL1 Q07820 1/20 0.49
MMP13 P45452 1/20 0.47
POLB P06746 3/20 0.47
AVPR2 P30518 1/20 0.46
GPR27 Q9NS67 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6792122 0.83 HDAC7 (0.59) SMN1; SMN2KMT2AHTTFLT1FLT4
SCHEMBL4766299 0.83 SMN1; SMN2 (0.57) SMN1; SMN2KMT2ARAB9AKDM4EMMP13
SCHEMBL5504399 0.82 SMN1; SMN2 (0.58) SMN1; SMN2KMT2AHTTFLT1FLT4
SCHEMBL20418534 0.82 TAS1R3 (0.55) KDRRAB9ANPC1TAS1R3TAS1R1
SCHEMBL13273316 0.82 HDAC6 (0.45) SMN1; SMN2KMT2AHTTFLT1FLT4
SCHEMBL8318320 0.80 FLT1 (0.59) SMN1; SMN2KMT2AFLT1FLT4KDR
SCHEMBL7706279 0.80 HPGD (0.59) SMN1; SMN2KMT2AFLT1FLT4KDR
SCHEMBL1003542 0.80 GAA (0.58) SMN1; SMN2KMT2AHTTRAB9ANPC1
SCHEMBL22226016 0.80 MAP2K1 (0.42) SMN1; SMN2KMT2AHTTFLT1FLT4
SCHEMBL1697081 0.80 FLT1 (0.54) KMT2AFLT1FLT4KDRRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5846990-A Substituted biphenyl isoxazole sulfonamides BRISTOL-MYERS SQUIBB CO. (US) 1998-12-08 US claimed
EP-0550557-B1 DETERGENT CONTAINING ALKYL SULFATE AND POLYHYDROXY FATTY ACID AMIDE SURFACTANTS PROCTER & GAMBLE (US) 1996-03-20 EP claimed
US-20240409523-A1 SUGAR AMIDES AND MIXTURES THEREOF CLARIANT INTERNATIONAL LTD (CH) 2024-12-12 US disclosed
EP-4408385-A1 SUGAR AMIDES AND MIXTURES THEREOF Clariant International Ltd (CH) 2024-08-07 EP disclosed
WO-2023065551-A1 AGGREGATE FORMED BY MEANS OF ASSEMBLING CHALCOGEN HETEROCYCLIC COMPOUND AND INSULIN, AND PREPARATION METHOD THEREFOR, AND INSULIN ORAL PREPARATION 福州大学 2023-04-27 WO disclosed
WO-2023052616-A1 SUGAR AMIDES AND MIXTURES THEREOF CLARIANT INTERNATIONAL LTD (CH) 2023-04-06 WO disclosed
US-20220008304-A1 MIXED SUGAR COMPOSITIONS PROCTER & GAMBLE (US) 2022-01-13 US disclosed
EP-3922247-A1 15-PGDH INHIBITOR Kyorin Pharmaceutical Co., Ltd. (JP) 2021-12-15 EP disclosed
US-9956548-B2 Preparation of an olefin oligomerization catalyst CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) 2018-05-01 US disclosed
EP-2896613-B1 SULFONAMIDE COMPOUND MITSUBISHI TANABE PHARMA CORP (JP) 2018-03-21 EP disclosed
EP-2964740-B1 MIXED SUGAR-BASED AMIDE SURFACTANT COMPOSITIONS PROCTER & GAMBLE (US) 2017-10-04 EP disclosed
US-20040077529-A1 Urotensin II receptor agents ACADIA PHARMACEUTICALS, INC. 2004-04-22 US disclosed
WO-2003104216-A1 UROTENSIN II RECEPTOR MODULATORS ACADIA PHARMACEUTICALS INC. (US) 2003-12-18 WO disclosed
US-20020013460-A1 Condensed pyridine compound EISAI CO., LTD 2002-01-31 US disclosed
US-6340759-B1 ANTISPASMODIC AGENTS EISAI CO., LTD. (JP) 2002-01-22 US disclosed
EP-1020445-A1 FUSED PYRIDINE DERIVATIVES Eisai Co., Ltd. (JP) 2000-07-19 EP disclosed
EP-0636625-B1 Tricyclic diazepines vasopressin and oxytocin antagonists AMERICAN CYANAMID CO (US) 1999-01-27 EP disclosed
CN-1178523-A Aminophenol derivatives DIICHI PHARMACEUTICAL CO LTD (JP) 1998-04-08 CN disclosed
US-4275213-A Isoxazolyl derivatives of 9α,11α-epoxy imino-9,11,15-trideoxy-PGF-type compounds THE UPJOHN COMPANY (US) 1981-06-23 US disclosed
US-4107311-A ANTI-FERTILITY AGENTS, ABORTIFACIENTS SANDOZ, INC. (US) 1978-08-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040077529-A1 Urotensin II receptor agents UTS2R, PLAUR, GPR17 SMN1; SMN2 2013/4885KMT2A 3931/4885HTT 2373/4885
US-20220008304-A1 MIXED SUGAR COMPOSITIONS MGAM, ABHD6, PHOSPHO1 SMN1; SMN2 669/4885KMT2A 865/4885HTT 1640/4885
US-20020013460-A1 Condensed pyridine compound MUSK, HTR1A, PAX3 SMN1; SMN2 27/4885KMT2A 1240/4885HTT 2446/4885
US-20240409523-A1 SUGAR AMIDES AND MIXTURES THEREOF UGCG, AMDHD2, MGAM SMN1; SMN2 3743/4885KMT2A 631/4885HTT 1813/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.