Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 3/20 | 0.33 |
| ▸ | MMP1 | P03956 | 2/20 | 0.33 |
| ▸ | MMP7 | P09237 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
| ▸ | MMP12 | P39900 | 1/20 | 0.33 |
| ▸ | SLC9A3 | P48764 | 4/20 | 0.33 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.32 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.32 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.32 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6863094 | 0.89 | MMP13 (0.37) | PDK2MMP13MMP1MMP7MMP8 | |
| SCHEMBL6864355 | 0.89 | MMP13 (0.47) | MMP13MMP1MMP7MMP8MMP12 | |
| SCHEMBL328416 | 0.88 | SMN1; SMN2 (0.35) | MMP13MMP1MMP7MMP8MMP12 | |
| SCHEMBL6852278 | 0.86 | CACNA1H (0.40) | MMP13MMP1MMP7MMP8MMP12 | |
| SCHEMBL328409 | 0.81 | MMP1 (0.38) | MMP13MMP1MMP7MMP8MMP12 | |
| SCHEMBL328403 | 0.80 | MEN1 (0.40) | ALDH1A1GAAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL328473 | 0.77 | F13A1 (0.41) | CACNA1HPTPN1LMNA | |
| SCHEMBL6863608 | 0.77 | MMP1 (0.47) | MMP13MMP1MMP7MMP8MMP12 | |
| SCHEMBL6852592 | 0.77 | CHRM5 (0.35) | MMP13MMP1MMP2MMP9KMT2A | |
| SCHEMBL328414 | 0.76 | DAGLA (0.37) | MMP2MMP9ALDH1A1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1511488-B1 | HUMAN ADAM-10 INHIBITORS | SYMPHONY EVOLUTION INC (US) | 2013-05-22 | — | — | EP | disclosed |
| EP-2428509-A1 | Human adam-10 inhibitors | Symphony Evolution, Inc. (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2011011181-A1 | PHARMACOLOGICAL CHAPERONES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | AMICUS THERAPEUTICS, INC. (US) | 2011-01-27 | — | — | WO | disclosed |