Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAGLA | Q9Y4D2 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.34 |
| ▸ | BMP1 | P13497 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL328661 | 0.91 | KMT2A (0.38) | DAGLAKMT2AALDH1A1L3MBTL1CA12 | |
| SCHEMBL328548 | 0.91 | DAGLA (0.37) | DAGLAKMT2AALDH1A1L3MBTL1CA12 | |
| SCHEMBL6850484 | 0.89 | DAGLA (0.36) | DAGLAKMT2AALDH1A1L3MBTL1POLB | |
| SCHEMBL328544 | 0.89 | DAGLA (0.35) | DAGLAKMT2AALDH1A1L3MBTL1CA12 | |
| SCHEMBL328649 | 0.89 | MMP1 (0.44) | KMT2ACA9BMP1MMP2MMP9 | |
| SCHEMBL6850664 | 0.87 | DAGLA (0.43) | DAGLAALDH1A1L3MBTL1POLBHPGD | |
| SCHEMBL6852280 | 0.85 | BDKRB1 (0.40) | DAGLAKMT2AALDH1A1L3MBTL1CA12 | |
| SCHEMBL10066710 | 0.85 | LSS (0.41) | DAGLAKMT2AALDH1A1L3MBTL1CA12 | |
| SCHEMBL328643 | 0.84 | KMT2A (0.35) | DAGLAKMT2AALDH1A1POLBCYP3A4 | |
| SCHEMBL6850244 | 0.83 | EDNRA (0.39) | DAGLAL3MBTL1CYP2C19MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428509-A1 | Human adam-10 inhibitors | Symphony Evolution, Inc. (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2011011181-A1 | PHARMACOLOGICAL CHAPERONES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | AMICUS THERAPEUTICS, INC. (US) | 2011-01-27 | — | — | WO | disclosed |