Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CETP | P11597 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP7 | P09237 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
| ▸ | MMP12 | P39900 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | SLC9A3 | P48764 | 4/20 | 0.33 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6863608 | 0.89 | MMP1 (0.47) | MMP1MMP7MMP8MMP12MMP13 | |
| SCHEMBL328408 | 0.88 | PDK2 (0.35) | SMN1; SMN2ALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL6852278 | 0.87 | CACNA1H (0.40) | SMN1; SMN2ALDH1A1KDM4ELMNAKMT2A | |
| SCHEMBL328473 | 0.82 | F13A1 (0.41) | LMNACACNA1H | |
| SCHEMBL328409 | 0.81 | MMP1 (0.38) | SMN1; SMN2ALDH1A1RAB9ALMNAKMT2A | |
| SCHEMBL328403 | 0.81 | MEN1 (0.40) | SMN1; SMN2ALDH1A1GAALMNAKMT2A | |
| SCHEMBL328418 | 0.79 | MMP1 (0.45) | ALDH1A1LMNAMMP1MMP7MMP8 | |
| SCHEMBL6852386 | 0.79 | MMP3 (0.38) | KMT2AMEN1MMP1MMP13PTGS2 | |
| SCHEMBL6850891 | 0.79 | ALDH1A1 (0.43) | SMN1; SMN2ALDH1A1NPC1RAB9ALMNA | |
| SCHEMBL328478 | 0.79 | LMNA (0.35) | LMNASLC9A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428509-A1 | Human adam-10 inhibitors | Symphony Evolution, Inc. (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2011011181-A1 | PHARMACOLOGICAL CHAPERONES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | AMICUS THERAPEUTICS, INC. (US) | 2011-01-27 | — | — | WO | disclosed |