Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F13A1 | P00488 | 1/20 | 0.41 |
| ▸ | TGM2 | P21980 | 1/20 | 0.41 |
| ▸ | TGM1 | P22735 | 1/20 | 0.41 |
| ▸ | DAGLA | Q9Y4D2 | 2/20 | 0.41 |
| ▸ | CACNA1H | O95180 | 4/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | PTGES | O14684 | 4/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 2/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6864863 | 0.90 | MMP2 (0.45) | F13A1TGM2TGM1DAGLACACNA1H | |
| SCHEMBL328662 | 0.85 | MEN1 (0.39) | DAGLAMAPTPGR | |
| SCHEMBL6850664 | 0.82 | DAGLA (0.43) | DAGLAPTPN1PGR | |
| SCHEMBL6852386 | 0.82 | MMP3 (0.38) | — | |
| SCHEMBL6852333 | 0.82 | MMP3 (0.39) | — | |
| SCHEMBL328416 | 0.82 | SMN1; SMN2 (0.35) | CACNA1HLMNA | |
| SCHEMBL328658 | 0.81 | HSP90AA1 (0.41) | DAGLAMAPTLMNA | |
| SCHEMBL328414 | 0.81 | DAGLA (0.37) | DAGLATHRBPGR | |
| SCHEMBL328659 | 0.81 | RORC (0.40) | — | |
| SCHEMBL6852592 | 0.81 | CHRM5 (0.35) | DAGLAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428509-A1 | Human adam-10 inhibitors | Symphony Evolution, Inc. (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2011011181-A1 | PHARMACOLOGICAL CHAPERONES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | AMICUS THERAPEUTICS, INC. (US) | 2011-01-27 | — | — | WO | disclosed |