Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAGLA | Q9Y4D2 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | BMP1 | P13497 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | SLC9A3 | P48764 | 5/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6864612 | 0.90 | BMP1 (0.42) | KMT2ABMP1 | |
| SCHEMBL328414 | 0.89 | DAGLA (0.37) | DAGLAKMT2ABMP1ALDH1A1L3MBTL1 | |
| SCHEMBL328544 | 0.88 | DAGLA (0.35) | DAGLAKMT2ABMP1ALDH1A1L3MBTL1 | |
| SCHEMBL328661 | 0.86 | KMT2A (0.38) | DAGLAKMT2ABMP1ALDH1A1L3MBTL1 | |
| SCHEMBL328548 | 0.86 | DAGLA (0.37) | DAGLAKMT2ABMP1ALDH1A1L3MBTL1 | |
| SCHEMBL6850664 | 0.83 | DAGLA (0.43) | DAGLAALDH1A1L3MBTL1SLC9A3POLB | |
| SCHEMBL6852280 | 0.82 | BDKRB1 (0.40) | DAGLAKMT2ABMP1ALDH1A1L3MBTL1 | |
| SCHEMBL328556 | 0.82 | MMP3 (0.40) | KMT2A | |
| SCHEMBL6850180 | 0.82 | MMP9 (0.40) | ALDH1A1GAA | |
| SCHEMBL328493 | 0.81 | TDP1 (0.44) | KMT2ABMP1LMNATDP1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428509-A1 | Human adam-10 inhibitors | Symphony Evolution, Inc. (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2011011181-A1 | PHARMACOLOGICAL CHAPERONES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | AMICUS THERAPEUTICS, INC. (US) | 2011-01-27 | — | — | WO | disclosed |