Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAGLA | Q9Y4D2 | 3/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | BMP1 | P13497 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | SLC9A3 | P48764 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL328414 | 0.91 | DAGLA (0.37) | DAGLACA12CA1CA9KMT2A | |
| SCHEMBL328661 | 0.90 | KMT2A (0.38) | DAGLACA12CA1CA9KMT2A | |
| SCHEMBL6864397 | 0.89 | MMP1 (0.44) | CA9KMT2ABMP1 | |
| SCHEMBL328544 | 0.88 | DAGLA (0.35) | DAGLACA12CA1CA9KMT2A | |
| SCHEMBL6850664 | 0.86 | DAGLA (0.43) | DAGLAALDH1A1L3MBTL1POLBHPGD | |
| SCHEMBL6850484 | 0.86 | DAGLA (0.36) | DAGLAKMT2AALDH1A1L3MBTL1POLB | |
| SCHEMBL10066710 | 0.84 | LSS (0.41) | DAGLACA12CA1CA9KMT2A | |
| SCHEMBL6852280 | 0.84 | BDKRB1 (0.40) | DAGLACA12CA1CA9KMT2A | |
| SCHEMBL328643 | 0.83 | KMT2A (0.35) | DAGLAKMT2AALDH1A1POLBCYP3A4 | |
| SCHEMBL6850244 | 0.82 | EDNRA (0.39) | DAGLAL3MBTL1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428509-A1 | Human adam-10 inhibitors | Symphony Evolution, Inc. (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2011011181-A1 | PHARMACOLOGICAL CHAPERONES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | AMICUS THERAPEUTICS, INC. (US) | 2011-01-27 | — | — | WO | disclosed |