SCHEMBL3284155

SCHEMBL3284155

c1ccc2c(c1)CC1=C2Cc2ccccc21

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 2/20 0.55
CES1 P23141 2/20 0.50
BCHE P06276 1/20 0.50
CHRM2 P08172 1/20 0.47
HTR1A P08908 1/20 0.47
ADRA2A P08913 1/20 0.47
CHRM1 P11229 1/20 0.47
DRD1 P21728 1/20 0.47
SLC6A2 P23975 1/20 0.47
SLC6A4 P31645 1/20 0.47
ADRA1A P35348 1/20 0.47
OPRM1 P35372 1/20 0.47
DRD3 P35462 1/20 0.47
SLC6A3 Q01959 1/20 0.47
KCNH2 Q12809 1/20 0.47
ALDH1A1 P00352 4/20 0.44
KDM4E B2RXH2 1/20 0.44
NPC1 O15118 1/20 0.44
LMNA P02545 1/20 0.44
MAPT P10636 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fluorene SCHEMBL545861 0.80 MAOA (0.68) MAOACES1BCHECHRM2HTR1A
Fluorene SCHEMBL31388525 0.80 MAOA (0.68) MAOACES1BCHECHRM2HTR1A
Fluorene SCHEMBL29355380 0.80 MAOA (0.68) MAOACES1BCHECHRM2HTR1A
Fluorene SCHEMBL29478468 0.80 MAOA (0.68) MAOACES1BCHECHRM2HTR1A
Fluorene SCHEMBL8180 0.80 MAOA (0.68) MAOACES1BCHECHRM2HTR1A
SCHEMBL17901678 0.78 ALOX15 (0.47) MAOACES1BCHECHRM2HTR1A
SCHEMBL2626979 0.78 CYP3A4 (0.46) MAOACES1BCHECHRM2HTR1A
SCHEMBL732656 0.78 MAOA (0.73) MAOACES1BCHEALDH1A1KDM4E
Fluorene SCHEMBL6739194 0.78 MAOA (0.65) MAOACES1BCHECHRM2HTR1A
Fluorene SCHEMBL10626727 0.78 MAOA (0.65) MAOACES1BCHECHRM2HTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3597184-B1 INDANONE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALTS OR OPTICAL ISOMERS THEREOF, PREPARATION METHOD FOR SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING VIRAL DISEASES KOREA RES INST CHEMICAL TECH (KR) 2026-03-04 EP disclosed
EP-2722042-B1 INDANONE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALTS OR OPTICAL ISOMERS THEREOF, PREPARATION METHOD FOR SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING VIRAL DISEASES KOREA RES INST CHEMICAL TECH (KR) 2019-05-29 EP disclosed
US-9890133-B2 Indanone derivatives, pharmaceutically acceptable salts or optical isomers thereof, preparation method for same, and pharmaceutical compositions containing same as active ingredient for preventing or treating viral diseases KATHOLIEKE UNIVERSITEIT LEUVEN K.U. LEUVEN R&D (BE) 2018-02-13 US disclosed
US-20160297789-A1 INDANONE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALTS OR OPTICAL ISOMERS THEREOF, PREPARATION METHOD FOR SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING VIRAL DISEASES KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2016-10-13 US disclosed
US-9464067-B2 Indanone derivatives, pharmaceutically acceptable salts or optical isomers thereof, preparation method for same, and pharmaceutical compositions containing same as active ingredient for preventing or treating viral diseases KATHOLIEKE UNIVERSITEIT LEUVEN K.U. LEUVEN R & D (BE) 2016-10-11 US disclosed
EP-2722042-A2 INDANONE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALTS OR OPTICAL ISOMERS THEREOF, PREPARATION METHOD FOR SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING VIRAL DISEASES Korea Research Institute of Chemical Technology (KR) 2014-04-23 EP disclosed
US-7705174-B2 Condensed polycyclic π-conjugated organic material, intermediate product therefor, and method of manufacturing condensed polycyclic π-conjugated organic material JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) 2010-04-27 US disclosed
US-20060100433-A1 n-conjugated organic material of polycyclic fused ring type,intermediate therefor, and process for producing n-conjugated organic material of polycyclic fused ring type JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) 2006-05-11 US disclosed
EP-1548019-A1 -CONJUGATED ORGANIC MATERIAL OF POLYCYCLIC FUSED RING TYPE, INTERMEDIATE THEREFOR, AND PROCESS FOR PRODUCING-CONJUGATED ORGANIC MATERIAL OF POLYCYCLIC FUSED RING TYPE Japan Science and Technology Agency (JP) 2005-06-29 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160297789-A1 INDANONE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALTS OR OPTICAL ISOMERS THEREOF, PREPARATION METHOD FOR SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING VIRAL DISEASES RNASE1, IAPP, TESK1 MAOA 365/4885CES1 3357/4885BCHE 2114/4885
US-20060100433-A1 n-conjugated organic material of polycyclic fused ring type,intermediate therefor, and process for producing n-conjugated organic material of polycyclic fused ring type SLC39A11, NQO1, SLC43A1 MAOA 2420/4885CES1 3073/4885BCHE 3146/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.