Triaziquone

Triaziquone

SCHEMBL3300089

O=C1C=C(N2CC2)C(=O)C(N2CC2)=C1N1CC1.OCNC(O)(O)O

nearest known ligand 0.35

Full drug profile on Sugi Atlas →

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
DNMT1 P26358 1/20 0.35
TP53 P04637 1/20 0.33
MAPT P10636 1/20 0.33
STAT3 P40763 1/20 0.33
HTT P42858 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Triaziquone SCHEMBL10698252 0.88 DNMT1 (0.33) DNMT1TP53MAPTSTAT3HTT
Triaziquone SCHEMBL3421294 0.87 MAPT (0.36) DNMT1TP53MAPTSTAT3HTT
Triaziquone SCHEMBL887253 0.83 MAPT (0.39) DNMT1TP53MAPTSTAT3HTT
Triaziquone SCHEMBL323176 0.83 MAPT (0.39) DNMT1TP53MAPTSTAT3HTT
Triaziquone SCHEMBL503952 0.81 TP53 (0.38) DNMT1TP53MAPTSTAT3HTT
Triaziquone SCHEMBL242425 0.80 DNMT1 (0.41) DNMT1TP53MAPTSTAT3HTT
Triaziquone SCHEMBL11350903 0.80 HTT (0.42) DNMT1TP53MAPTSTAT3HTT
Triaziquone SCHEMBL108508 0.80 DNMT1 (0.41) DNMT1TP53MAPTSTAT3HTT
Triaziquone SCHEMBL5800741 0.80 DNMT1 (0.41) DNMT1TP53MAPTSTAT3HTT
Triaziquone SCHEMBL3903404 0.80 DNMT1 (0.32) DNMT1TP53MAPTSTAT3HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11806402-B2 Sulfoalkyl ether cyclodextrin compositions CYDEX PHARMACEUTICALS, INC. (US) 2023-11-07 US disclosed
US-11795241-B2 Fractionated alkylated cyclodextrin compositions and processes for preparing and using the same CYDEX PHARMACEUTICALS, INC. (US) 2023-10-24 US disclosed
US-20210147582-A1 FRACTIONATED ALKYLATED CYCLODEXTRIN COMPOSITIONS AND PROCESSES FOR PREPARING AND USING THE SAME CITIBANK, N.A., AS ADMINISTRATIVE AGENT 2021-05-20 US disclosed
US-20210093727-A1 SULFOALKYL ETHER CYCLODEXTRIN COMPOSITIONS CITIBANK, N.A., AS ADMINISTRATIVE AGENT 2021-04-01 US disclosed
US-10851184-B2 Fractionated alkylated cyclodextrin compositions and processes for preparing and using the same CYDEX PHARMACEUTICALS, INC. (US) 2020-12-01 US disclosed
US-10800861-B2 Alkylated cyclodextrin compositions and processes for preparing and using the same CYDEX PHARMACEUTICALS, INC. (US) 2020-10-13 US disclosed
US-10780177-B2 Sulfoalkyl ether cyclodextrin compositions CYDEX PHARMACEUTICALS, INC. (US) 2020-09-22 US disclosed
US-10323103-B2 Alkylated cyclodextrin compositions and processes for preparing and using the same CYDEX PHARMACEUTICALS, INC. (US) 2019-06-18 US disclosed
US-20190070303-A1 SULFOALKYL ETHER CYCLODEXTRIN COMPOSITIONS CITIBANK, N.A., AS ADMINISTRATIVE AGENT 2019-03-07 US disclosed
US-20180346609-A1 ALKYLATED CYCLODEXTRIN COMPOSITIONS AND PROCESSES FOR PREPARING AND USING THE SAME CITIBANK, N.A., AS ADMINISTRATIVE AGENT 2018-12-06 US disclosed
US-9200088-B2 Sulfoalkyl ether cyclodextrin compositions CYDEX PHARMACEUTICALS, INC. (US) 2015-12-01 US disclosed
US-20150284479-A1 ALKYLATED CYCLODEXTRIN COMPOSITIONS AND PROCESSES FOR PREPARING AND USING THE SAME CITIBANK, N.A., AS ADMINISTRATIVE AGENT 2015-10-08 US disclosed
US-20150045311-A1 ALKYLATED CYCLODEXTRIN COMPOSITIONS AND PROCESSES FOR PREPARING AND USING THE SAME CITIBANK, N.A., AS ADMINISTRATIVE AGENT 2015-02-12 US disclosed
US-20130184357-A1 SULFOALKYL ETHER CYCLODEXTRIN COMPOSITIONS CYDEX PHARMACEUTICALS, INC. (US) 2013-07-18 US disclosed
US-8410077-B2 Sulfoalkyl ether cyclodextrin compositions CYDEX PHARMACEUTICALS, INC. (US) 2013-04-02 US disclosed
US-8383606-B2 2013-02-26 US disclosed
US-20100093663-A1 Sulfoalkyl Ether Cyclodextrin Compositions CYDEX PHARMACEUTICALS, INC. (US) 2010-04-15 US disclosed
US-7635773-B2 Sulfoalkyl ether cyclodextrin compositions CYDEX PHARMACEUTICALS, INC. (US) 2009-12-22 US disclosed
US-20090270348-A1 Sulfoalkyl Ether Cyclodextrin Compositions CITIBANK, N.A., AS ADMINISTRATIVE AGENT 2009-10-29 US disclosed
WO-2009018069-A2 MIXTURES OF CYCLODEXTRIN DERIVATIVES CYDEX PHARMACEUTICALS, INC (US) 2009-02-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (14 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150284479-A1 ALKYLATED CYCLODEXTRIN COMPOSITIONS AND PROCESSES FOR PREPARING AND USING THE SAME AGL, AGPS, MGAM DNMT1 996/4885TP53 3820/4885MAPT 3069/4885
US-11795241-B2 Fractionated alkylated cyclodextrin compositions and processes for preparing and using the same AGPS, DDOST, ALG1 DNMT1 1914/4885TP53 2173/4885MAPT 2876/4885
US-10323103-B2 Alkylated cyclodextrin compositions and processes for preparing and using the same AGL, AGPS, MGAM DNMT1 996/4885TP53 3820/4885MAPT 3069/4885
US-20090270348-A1 Sulfoalkyl Ether Cyclodextrin Compositions SI, SULT1E1, SAE1 DNMT1 1447/4885TP53 1262/4885MAPT 1472/4885
US-20210147582-A1 FRACTIONATED ALKYLATED CYCLODEXTRIN COMPOSITIONS AND PROCESSES FOR PREPARING AND USING THE SAME AGPS, DDOST, ALG1 DNMT1 1914/4885TP53 2173/4885MAPT 2876/4885
US-20100093663-A1 Sulfoalkyl Ether Cyclodextrin Compositions SI, SULT1E1, SAE1 DNMT1 1257/4885TP53 1509/4885MAPT 1744/4885
US-20150045311-A1 ALKYLATED CYCLODEXTRIN COMPOSITIONS AND PROCESSES FOR PREPARING AND USING THE SAME AGL, AGPS, MGAM DNMT1 996/4885TP53 3820/4885MAPT 3069/4885
US-10800861-B2 Alkylated cyclodextrin compositions and processes for preparing and using the same AGL, AGPS, MGAM DNMT1 996/4885TP53 3820/4885MAPT 3069/4885
US-20180346609-A1 ALKYLATED CYCLODEXTRIN COMPOSITIONS AND PROCESSES FOR PREPARING AND USING THE SAME AGL, AGPS, MGAM DNMT1 996/4885TP53 3820/4885MAPT 3069/4885
US-20190070303-A1 SULFOALKYL ETHER CYCLODEXTRIN COMPOSITIONS SI, SULT1E1, SAE1 DNMT1 1257/4885TP53 1509/4885MAPT 1744/4885
US-20210093727-A1 SULFOALKYL ETHER CYCLODEXTRIN COMPOSITIONS SI, SULT1E1, SAE1 DNMT1 1257/4885TP53 1509/4885MAPT 1744/4885
US-10780177-B2 Sulfoalkyl ether cyclodextrin compositions SI, SULT1E1, SAE1 DNMT1 1257/4885TP53 1509/4885MAPT 1744/4885
US-10851184-B2 Fractionated alkylated cyclodextrin compositions and processes for preparing and using the same AGPS, DDOST, ALG1 DNMT1 1914/4885TP53 2173/4885MAPT 2876/4885
US-11806402-B2 Sulfoalkyl ether cyclodextrin compositions SI, SULT1E1, SAE1 DNMT1 1257/4885TP53 1509/4885MAPT 1744/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.