Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.58 |
| ▸ | APLNR | P35414 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.52 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27880581 | 0.90 | LTA4H (0.51) | LTA4HAPLNRALDH1A1KDM4EMAPT | |
| SCHEMBL5612174 | 0.89 | APLNR (0.59) | LTA4HAPLNRALDH1A1MAPTTSHR | |
| SCHEMBL27563776 | 0.87 | MAOB (0.57) | LTA4HALDH1A1MTNR1AMTNR1B | |
| SCHEMBL11288852 | 0.86 | LTA4H (0.58) | LTA4HALDH1A1MTNR1AMTNR1BGPR55 | |
| SCHEMBL145084 | 0.85 | APLNR (0.68) | APLNRALDH1A1MAPTTSHR | |
| SCHEMBL11399635 | 0.84 | KDM4E (0.59) | APLNRALDH1A1KDM4EMAPT | |
| SCHEMBL28745363 | 0.83 | MTNR1A (0.57) | LTA4HALDH1A1KDM4EMAPTMTNR1A | |
| SCHEMBL5612171 | 0.83 | APLNR (0.53) | LTA4HAPLNRALDH1A1MAPTTSHR | |
| SCHEMBL9291320 | 0.83 | MAPK1 (0.61) | APLNRALDH1A1MAPTTSHR | |
| SCHEMBL11292183 | 0.82 | LTA4H (0.58) | LTA4HALDH1A1MTNR1AMTNR1BGPR55 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8492384-B2 | Imidazolylalkylcarbonyl derivatives as calcium channel modulators and preparation method thereof | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2013-07-23 | — | — | US | claimed |
| US-20090325979-A1 | NOVEL IMIDAZOLYLALKYLCARBONYL DERIVATIVES AS CALCIUM CHANNEL MODULATORS AND PREPARATION METHOD THEREOF | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2009-12-31 | — | — | US | claimed |
| CN-115894284-B | New compound separated from Taiwan pseudogolden moss and preparation method and application thereof | 河北中医学院 | 2023-05-30 | — | — | CN | disclosed |
| US-20160280693-A1 | ACTIVATORS OF CLASS I HISTONE DEACETLYASES (HDACS) AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2016-09-29 | — | — | US | disclosed |
| US-9115053-B2 | Activators of class I histone deacetlyases (HDACS) and uses thereof | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2015-08-25 | — | — | US | disclosed |
| US-8492384-B2 | Imidazolylalkylcarbonyl derivatives as calcium channel modulators and preparation method thereof | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2013-07-23 | — | — | US | disclosed |
| US-20130096129-A1 | ACTIVATORS OF CLASS I HISTONE DEACETLYASES (HDACS) AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2013-04-18 | — | — | US | disclosed |
| US-8299072-B2 | Pyrazolylmethylamine compounds as calcium channel modulators and preparation method thereof | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2012-10-30 | — | — | US | disclosed |
| US-20100094006-A1 | NOVEL PYRAZOLYLMETHYLAMINE COMPOUNDS AS CALCIUM CHANNEL MODULATORS AND PREPARATION METHOD THEREOF | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2010-04-15 | — | — | US | disclosed |
| US-20090325979-A1 | NOVEL IMIDAZOLYLALKYLCARBONYL DERIVATIVES AS CALCIUM CHANNEL MODULATORS AND PREPARATION METHOD THEREOF | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2009-12-31 | — | — | US | disclosed |
| EP-1361225-B1 | COMPOUNDS SUBSTITUTED WITH BICYCLIC AMINO GROUPS | SANKYO CO (JP) | 2007-11-07 | — | — | EP | disclosed |
| US-20040054173-A1 | Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses | SANKYO COMPANY, LIMITED (JP) | 2004-03-18 | — | — | US | disclosed |
| EP-1377577-A1 | PYRROLE DERIVATES FOR TREATING CYTOKINE MEDIATED DISEASES | Sankyo Company Limited (JP) | 2004-01-07 | — | — | EP | disclosed |
| EP-1361225-A1 | COMPOUNDS SUBSTITUTED WITH BICYCLIC AMINO GROUPS | Sankyo Company, Limited (JP) | 2003-11-12 | — | — | EP | disclosed |
| EP-1352906-A1 | COMPOSITIONS FOR PREVENTION OR TREATMENT OF HEPATOPATHY | Sankyo Company, Limited (JP) | 2003-10-15 | — | — | EP | disclosed |
| EP-1243589-A1 | Heteroaryl-substituted pyrrole derivates, their preparation and their therapeutic uses | Sankyo Company Limited (JP) | 2002-09-25 | — | — | EP | disclosed |
| WO-2002057264-A1 | PYRROLE DERIVATES FOR TREATING CYTOKINE MEDIATED DISEASES | SANKYO COMPANY LIMITED (JP) | 2002-07-25 | — | — | WO | disclosed |
| EP-1070711-A2 | Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |
| EP-0057740-A1 | Pressure sensitive recording sheets | DIAMOND SHAMROCK CORPORATION (US) | 1982-08-18 | — | — | EP | disclosed |
| US-4275906-A | Pressure sensitive recording sheets | DIAMOND SHAMROCK CORPORATION (US) | 1981-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160280693-A1 | ACTIVATORS OF CLASS I HISTONE DEACETLYASES (HDACS) AND USES THEREOF | TDP1, PDS5A, CDK5 | LTA4H 2948/4885APLNR 4849/4885ALDH1A1 2598/4885 |
| US-20130096129-A1 | ACTIVATORS OF CLASS I HISTONE DEACETLYASES (HDACS) AND USES THEREOF | HDAC1, HDAC11, HDAC6 | LTA4H 2311/4885APLNR 4170/4885ALDH1A1 283/4885 |
| US-20040054173-A1 | Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses | IL2, IL1B, IL1A | LTA4H 995/4885APLNR 1391/4885ALDH1A1 1023/4885 |
| US-20090325979-A1 | NOVEL IMIDAZOLYLALKYLCARBONYL DERIVATIVES AS CALCIUM CHANNEL MODULATORS AND PREPARATION METHOD THEREOF | CACNA1B, CACNA1C, ORAI1 | LTA4H 1184/4885APLNR 1563/4885ALDH1A1 3972/4885 |
| US-20100094006-A1 | NOVEL PYRAZOLYLMETHYLAMINE COMPOUNDS AS CALCIUM CHANNEL MODULATORS AND PREPARATION METHOD THEREOF | CACNA1I, CACNA1C, ORAI1 | LTA4H 1458/4885APLNR 762/4885ALDH1A1 4048/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.