Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 13/20 | 0.51 |
| ▸ | HTR2C | P28335 | 7/20 | 0.51 |
| ▸ | HTR1D | P28221 | 4/20 | 0.41 |
| ▸ | HTR3A | P46098 | 4/20 | 0.41 |
| ▸ | HTR2A | P28223 | 3/20 | 0.41 |
| ▸ | HTR6 | P50406 | 2/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | HTR1E | P28566 | 3/20 | 0.38 |
| ▸ | HTR5A | P47898 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12469329 | 0.79 | HTR2B (0.58) | HTR2BHTR2CHTR1DHTR3AHTR2A | |
| SCHEMBL15423915 | 0.73 | HTR2B (0.44) | HTR2BHTR2CHTR1DHTR3AHTR2A | |
| SCHEMBL3372129 | 0.69 | HTR2B (0.46) | HTR2BHTR2CMAPTHSD17B10ALDH1A1 | |
| SCHEMBL3329469 | 0.69 | HTR2B (0.43) | HTR2BHTR2CHTR1DHTR3AHTR2A | |
| Pulicatin A SCHEMBL19307974 | 0.68 | HTR2B (1.00) | HTR2BHTR2CHTR1DHTR3AHTR2A | |
| Pulicatin A SCHEMBL15412607 | 0.68 | HTR2B (1.00) | HTR2BHTR2CHTR1DHTR3AHTR2A | |
| Pulicatin A SCHEMBL15423013 | 0.68 | HTR2B (1.00) | HTR2BHTR2CHTR1DHTR3AHTR2A | |
| Pulicatin A SCHEMBL15412524 | 0.68 | HTR2B (1.00) | HTR2BHTR2CHTR1DHTR3AHTR2A | |
| SCHEMBL1686982 | 0.68 | HTR2B (0.76) | HTR2BHTR2CHTR1DHTR3AHTR7 | |
| SCHEMBL30608416 | 0.68 | HTR2B (0.76) | HTR2BHTR2CHTR1DHTR3AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9730917-B2 | Desferrithiocin polyether analogues | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2017-08-15 | — | — | US | disclosed |
| EP-2137170-B1 | DESFERRITHIOCIN POLYETHER ANALOGUES | UNIV FLORIDA (US) | 2016-03-09 | — | — | EP | disclosed |
| US-20160022645-A1 | DESFERRITHIOCIN POLYETHER ANALOGUES | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2016-01-28 | — | — | US | disclosed |
| US-9174948-B2 | Desferrithiocin polyether analogues | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2015-11-03 | — | — | US | disclosed |
| US-20130210870-A1 | DESFERRITHIOCIN POLYETHER ANALOGUES | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2013-08-15 | — | — | US | disclosed |
| US-8324397-B2 | Desferrithiocin polyether analogues | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2012-12-04 | — | — | US | disclosed |
| US-20100093812-A1 | DESFERRITHIOCIN POLYETHER ANALOGUES | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2010-04-15 | — | — | US | disclosed |
| EP-2137170-A1 | DESFERRITHIOCIN POLYETHER ANALOGUES | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008115433-A1 | DESFERRITHIOCIN POLYETHER ANALOGUES | UNIVERSITY OF FLORIDA (US) | 2008-09-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160022645-A1 | DESFERRITHIOCIN POLYETHER ANALOGUES | HAMP, SLC40A1, FTH1 | HTR2B 3611/4885HTR2C 3994/4885HTR1D 3694/4885 |
| US-20100093812-A1 | DESFERRITHIOCIN POLYETHER ANALOGUES | SLC40A1, HAMP, FTH1 | HTR2B 3792/4885HTR2C 3961/4885HTR1D 3650/4885 |
| US-20130210870-A1 | DESFERRITHIOCIN POLYETHER ANALOGUES | HAMP, SLC40A1, FTH1 | HTR2B 3611/4885HTR2C 3994/4885HTR1D 3694/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.