Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 3/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11729095 | 0.82 | TSHR (0.41) | CYP3A4TDP1KMT2AMEN1CYP2C9 | |
| SCHEMBL6573773 | 0.81 | ALDH1A1 (0.44) | ALDH1A1KCNH2MAPTL3MBTL1 | |
| SCHEMBL11722993 | 0.74 | CYP2C19 (0.39) | TDP1KMT2AMEN1CYP2C19SMN1; SMN2 | |
| SCHEMBL16755617 | 0.72 | TDP1 (0.43) | CYP3A4TDP1KMT2AMEN1CYP2C9 | |
| SCHEMBL19530997 | 0.72 | CYP3A4 (0.43) | CYP3A4TDP1KDM4EESR1ESR2 | |
| SCHEMBL2576486 | 0.72 | TDP1 (0.43) | CYP3A4TDP1KMT2AMEN1CYP2C9 | |
| SCHEMBL2574194 | 0.70 | MEN1 (0.42) | CYP3A4TDP1KMT2AMEN1ALDH1A1 | |
| SCHEMBL14271678 | 0.68 | TAAR1 (0.39) | CYP3A4TDP1KMT2AALDH1A1TSHR | |
| SCHEMBL28635021 | 0.68 | TDP1 (0.50) | CYP3A4TDP1ALDH1A1TSHRGLA | |
| SCHEMBL14938874 | 0.67 | TDP1 (0.38) | CYP3A4TDP1KMT2AMEN1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100099898-A1 | Processes and Intermediates For Preparing Benzyle Epoxides | ELAN PHARMACEUTICALS, INC. | 2010-04-22 | — | — | US | disclosed |
| EP-1381597-B1 | PROCESS FOR PREPARING HYDROXYETHYLAMINES | ELAN PHARM INC (US) | 2008-07-16 | — | — | EP | disclosed |
| EP-1395551-B1 | HYDROXY ALKYL AMINE DERIVATIVES AS BETA-SECRETASE INHIBITORS AND THEIR USE FOR THE TREATMENT OF ALZHEIMER'S DISEASE AND SIMILAR DISEASES | ELAN PHARM INC (US) | 2008-05-21 | — | — | EP | disclosed |
| US-20080096942-A1 | Substituted Hydroxyethylamines | ELAN PHARMACEUTICALS, INC. | 2008-04-24 | — | — | US | disclosed |
| US-7351849-B2 | Process for producing optically active β-amino acid derivatives | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2008-04-01 | — | — | US | disclosed |
| US-20070299263-A1 | Hydroxy Alkyl Amines | Elan Pharmaceuticals, Inc. and Pharmacia & Upjohn Company | 2007-12-27 | — | — | US | disclosed |
| US-7312360-B2 | Substituted hydroxyethylamines | ELAN PHARMACEUTICALS, INC. (US) | 2007-12-25 | — | — | US | disclosed |
| US-7144897-B2 | Hydroxy alkyl amines | Elan Oharmaceuticals, Inc. (US) | 2006-12-05 | — | — | US | disclosed |
| US-20060205968-A1 | Process for producing optically active beta-amino acid derivatives | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2006-09-14 | — | — | US | disclosed |
| US-6849750-B2 | Processes and intermediates for preparing benzyl epoxides | PHARMACIA & UPJOHN COMPANY LLC (US) | 2005-02-01 | — | — | US | disclosed |
| US-20040044072-A1 | Substituted hydroxyethylamines | PHARMACIA & UPJOHN COMPANY | 2004-03-04 | — | — | US | disclosed |
| US-20030166717-A1 | Hydroxy alkyl amines | FRESKOS JOHN (US) | 2003-09-04 | — | — | US | disclosed |
| US-20030004360-A1 | Processes and intermediates for preparing benzyl epoxides | PHARMACIA & UPJOHN COMPANY | 2003-01-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080096942-A1 | Substituted Hydroxyethylamines | BACE1, BACE2, MME | CYP3A4 584/4885TDP1 400/4885KMT2A 528/4885 |
| US-20030166717-A1 | Hydroxy alkyl amines | PSEN1, MAOA, PSEN2 | CYP3A4 879/4885TDP1 189/4885KMT2A 1368/4885 |
| US-20040044072-A1 | Substituted hydroxyethylamines | BACE1, BACE2, PSEN1 | CYP3A4 737/4885TDP1 257/4885KMT2A 704/4885 |
| US-20100099898-A1 | Processes and Intermediates For Preparing Benzyle Epoxides | VKORC1, EPOR, POR | CYP3A4 35/4885TDP1 3959/4885KMT2A 4391/4885 |
| US-20030004360-A1 | Processes and intermediates for preparing benzyl epoxides | CYP2F1, VKORC1, VKORC1L1 | CYP3A4 14/4885TDP1 3808/4885KMT2A 4509/4885 |
| US-20060205968-A1 | Process for producing optically active beta-amino acid derivatives | BCAT1, ALAD, AADAT | CYP3A4 1790/4885TDP1 4754/4885KMT2A 2991/4885 |
| US-20070299263-A1 | Hydroxy Alkyl Amines | MAOA, PSEN2, PSEN1 | CYP3A4 936/4885TDP1 428/4885KMT2A 1229/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.