Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRZ1 | P23471 | 4/20 | 0.65 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.65 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.41 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.34 |
| ▸ | KCNK10 | P57789 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL515523 | 0.80 | PTPRZ1 (0.42) | PTPRZ1PTPN1EPHX2NR1H4ALDH1A1 | |
| SCHEMBL3310758 | 0.76 | ALDH1A1 (0.46) | EPHX2ALDH1A1KIF11NAMPT | |
| SCHEMBL3306295 | 0.75 | PTPRZ1 (0.70) | PTPRZ1PTPN1EPHX2NR1H4ALDH1A1 | |
| SCHEMBL13123457 | 0.73 | PTPRZ1 (0.79) | PTPRZ1PTPN1EPHX2NR1H4ALDH1A1 | |
| SCHEMBL5542842 | 0.73 | CA2 (0.33) | PTPRZ1PTPN1EPHX2NR1H4ALDH1A1 | |
| SCHEMBL1486307 | 0.72 | LMNA (0.47) | ALDH1A1NPC1RAB9ACA1CA2 | |
| SCHEMBL95318 | 0.72 | PTPRZ1 (0.61) | PTPRZ1PTPN1EPHX2NR1H4ALDH1A1 | |
| SCHEMBL11081323 | 0.72 | PTPRZ1 (0.69) | PTPRZ1PTPN1EPHX2NR1H4ALDH1A1 | |
| SCHEMBL6001747 | 0.72 | PTPRZ1 (0.65) | PTPRZ1PTPN1EPHX2NR1H4ALDH1A1 | |
| SCHEMBL18998006 | 0.72 | PTPRZ1 (0.65) | PTPRZ1PTPN1EPHX2NR1H4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100099676-A1 | SULFONYLUREA DERIVATIVE CAPABLE OF SELECTIVELY INHIBITING MMP-13 | SHIONOGI & CO., LTD. (JP) | 2010-04-22 | — | — | US | disclosed |
| EP-2128134-A1 | SULFONYLUREA DERIVATIVE CAPABLE OF SELECTIVELY INHIBITING MMP-13 | Shionogi&Co., Ltd. (JP) | 2009-12-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100099676-A1 | SULFONYLUREA DERIVATIVE CAPABLE OF SELECTIVELY INHIBITING MMP-13 | MMP13, MMP3, MMP26 | PTPRZ1 3926/4885PTPN1 2291/4885EPHX2 3735/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.