Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2071309 | 0.81 | CYP2C19 (0.46) | ALOX5CES2CES1KEAP1CYP2C19 | |
| SCHEMBL10210730 | 0.76 | ALOX5 (0.50) | ALOX5CES2CES1KEAP1CYP2C19 | |
| SCHEMBL27347276 | 0.76 | ALOX5 (0.42) | ALOX5CES2CES1KEAP1CYP2C19 | |
| SCHEMBL6464486 | 0.76 | ALOX5 (0.50) | ALOX5CES2CES1KEAP1CYP2C19 | |
| SCHEMBL14782240 | 0.76 | ALOX5 (0.40) | ALOX5CES2CES1KEAP1CYP2C19 | |
| SCHEMBL25358790 | 0.74 | MME (0.43) | ALOX5CES2CES1KEAP1GAA | |
| SCHEMBL30174080 | 0.74 | HPGD (0.41) | ALOX5CES2CES1KEAP1CYP2C19 | |
| SCHEMBL667372 | 0.74 | HPGD (0.41) | ALOX5CES2CES1KEAP1CYP2C19 | |
| SCHEMBL10541760 | 0.74 | LDHA (0.45) | LMNASMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL20899846 | 0.73 | GAA (0.42) | ALOX5CES2CES1KEAP1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8263787-B2 | Process for preparing dorzolamide | CIPLA LIMITED (IN) | 2012-09-11 | — | — | US | disclosed |
| US-20100113804-A1 | Process for Preparing Dorzolamide | CIPLA LIMITED (IN) | 2010-05-06 | — | — | US | disclosed |
| EP-2152718-A2 | PROCESS FOR PREPARING DORZOLAMIDE | Cipla Limited (IN) | 2010-02-17 | — | — | EP | disclosed |
| US-20090137821-A1 | Method of making dorzolamide hydrochloride | KOVACS LASZLO ZSOLT | 2009-05-28 | — | — | US | disclosed |
| WO-2008135770-A2 | PROCESS FOR PREPARING DORZOLAM IDE | CIPLA LIMITED (IN) | 2008-11-13 | — | — | WO | disclosed |
| CN-101098874-A | Method of making dorzolamide hydrochloride | TEVA GYOGYSZERGYAR ZARTKOER EN (HU) | 2008-01-02 | — | — | CN | disclosed |
| EP-1753769-A2 | METHOD OF MAKING DORZOLAMIDE HYDROCHLORIDE | TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság (HU) | 2007-02-21 | — | — | EP | disclosed |
| US-20060155132-A1 | Method of making dorzolamide hydrochloride | TEVA PHARMACEUTICALS USA, INC. | 2006-07-13 | — | — | US | disclosed |
| WO-2006074230-A2 | METHOD OF MAKING DORZOLAMIDE HYDROCHLORIDE | TEVA GYÓGYSZERGYÁR ZÁRTKÖRÜEN MÜKÖDÖ RÉSZVÉNYTÁRSASÁG (HU) | 2006-07-13 | — | — | WO | disclosed |
| US-7030250-B2 | Process for obtaining 4-(N-alkylamino)-5,6-dihydro-4H-thien-(2,3-b)-thiopyran-2-sulfonamide-7,7-dioxides and intermediates | RAGATIVES, S.L. (ES) | 2006-04-18 | — | — | US | disclosed |
| EP-1329453-B1 | METHOD FOR OBTAINING 4-(N-ALKYLAMINE)-5, 6-DIHYDRO-4H-THIENO-(2,3-B)-THIOPYRAN-2-SULFONAMIDE-7, 7-DIOXIDES AND INTERMEDIATE PRODUCTS | RAGACTIVES SL (ES) | 2004-06-16 | — | — | EP | disclosed |
| US-20030220509-A1 | Process for obtaining 4-(N-alkylamino)-5,6-dihydro-4H-thien-(2,3-b)-thiopyran-2-sulfonamide-7,7-dioxides and intermediates | RAGACTIVES, S.L. | 2003-11-27 | — | — | US | disclosed |
| EP-1329453-A1 | METHOD FOR OBTAINING 4-(N-ALKYLAMINE)-5, 6-DIHYDRO-4H-THIENO-(2,3-B)-THIOPYRAN-2-SULFAMIDE-7, 7-DIOXIDES AND INTERMEDIATE PRODUCTS | Ragactives, S.L. (ES) | 2003-07-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113804-A1 | Process for Preparing Dorzolamide | SQOR, PPOX, DAO | ALOX5 782/4885CES2 1277/4885CES1 724/4885 |
| US-20060155132-A1 | Method of making dorzolamide hydrochloride | CYP3A4, CYP3A43, CYP2C19 | ALOX5 513/4885CES2 584/4885CES1 101/4885 |
| US-20030220509-A1 | Process for obtaining 4-(N-alkylamino)-5,6-dihydro-4H-thien-(2,3-b)-thiopyran-2-sulfonamide-7,7-dioxides and intermediates | CA7, CA2, CA4 | ALOX5 816/4885CES2 1116/4885CES1 66/4885 |
| US-20090137821-A1 | Method of making dorzolamide hydrochloride | CYP3A4, CYP3A43, CYP2C19 | ALOX5 513/4885CES2 584/4885CES1 101/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.