Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 2/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | USP8 | P40818 | 1/20 | 0.32 |
| ▸ | USP7 | Q93009 | 1/20 | 0.32 |
| ▸ | MGAT2 | Q10469 | 3/20 | 0.31 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | PDE9A | O76083 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3303729 | 0.89 | AR (0.36) | ERBB2CYP11B1CYP11B2GAAAR | |
| SCHEMBL10015880 | 0.89 | CHEK1 (0.39) | CYP11B1CYP11B2KDM4ENPC1ALDH1A1 | |
| SCHEMBL3966184 | 0.85 | RAPGEF4 (0.38) | CYP11B1CYP11B2MAPTRAPGEF4KDM4E | |
| SCHEMBL3311229 | 0.81 | RAPGEF4 (0.35) | CYP11B1CYP11B2RAPGEF4NPC1RAB9A | |
| SCHEMBL3311654 | 0.79 | PTGES (0.39) | ERBB2GAAARMAPTKDM4E | |
| SCHEMBL1873945 | 0.78 | KMT2A (0.34) | MAPTRAPGEF4KDM4ENPC1ALDH1A1 | |
| SCHEMBL29355159 | 0.77 | CHEK1 (0.41) | ERBB2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL10015938 | 0.77 | CHEK1 (0.41) | ERBB2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL3971627 | 0.73 | RAB9A (0.39) | MAPTRAPGEF4NPC1ALDH1A1RAB9A | |
| SCHEMBL1043323 | 0.73 | ACHE (0.48) | RAPGEF4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100113457-A1 | NOVEL PYRIDAZINE DERIVATIVES | SYNGENTA CROP PROTECTION, INC. (US) | 2010-05-06 | — | — | US | claimed |
| US-20100113457-A1 | NOVEL PYRIDAZINE DERIVATIVES | SYNGENTA CROP PROTECTION, INC. (US) | 2010-05-06 | — | — | US | disclosed |
| EP-2121629-A1 | NOVEL PYRIDAZINE DERIVATIVES | Syngeta Participations AG (CH) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008049584-A1 | NOVEL PYRIDAZINE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2008-05-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113457-A1 | NOVEL PYRIDAZINE DERIVATIVES | C3AR1, C5, C1S | ERBB2 3678/4885CYP11B1 657/4885CYP11B2 809/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.