Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | PARP1 | P09874 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | BPTF | Q12830 | 2/20 | 0.38 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23231062 | 0.80 | BRD4 (0.43) | HPGDLMNAMAPK1HTTTBXAS1 | |
| SCHEMBL31364631 | 0.79 | HPGD (0.41) | ATMHPGDALDH1A1HSD17B10PARP1 | |
| SCHEMBL16131514 | 0.79 | HPGD (0.44) | KMT2AHPGDALDH1A1LMNAMAPK1 | |
| SCHEMBL23231094 | 0.79 | HPGD (0.41) | MEN1KMT2AATMHPGDALDH1A1 | |
| SCHEMBL24207796 | 0.77 | ALDH1A1 (0.39) | KEAP1MEN1USP2KMT2AATM | |
| SCHEMBL23231095 | 0.76 | ALDH1A1 (0.54) | KMT2AATMHPGDALDH1A1HSD17B10 | |
| SCHEMBL31364630 | 0.76 | HTT (0.43) | MEN1KMT2AATMHPGDALDH1A1 | |
| SCHEMBL24207479 | 0.76 | BPTF (0.36) | KEAP1MEN1USP2KMT2AATM | |
| SCHEMBL619809 | 0.76 | MKNK1 (0.43) | KEAP1MEN1USP2KMT2AATM | |
| SCHEMBL30006645 | 0.76 | MKNK1 (0.43) | KEAP1MEN1USP2KMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8461346-B2 | Benzyl amines, a process for their production and their use as anti-inflammatory agents | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2013-06-11 | — | — | US | disclosed |
| US-20120289510-A1 | Benzyl Amines, A Process For Their Production And Their Use As Anti-Inflammtory Agents | ASTRAZENECA AB (SE) | 2012-11-15 | — | — | US | disclosed |
| WO-2012025578-A3 | AN APPLICATOR FOR APPLYING A COSMETIC COMPOSITION AND A COSMETIC PACKAGING INCLUDING SUCH AN APPLICATOR | ALBEA SERVICES (FR) | 2012-05-10 | — | — | WO | disclosed |
| US-8173676-B2 | Benzyl, amines, a process for their production and their use as anti-inflammatory agents | Bayer Pharma AG (DE) | 2012-05-08 | — | — | US | disclosed |
| US-8097627-B2 | Multiply-substituted tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents | Bayer Pharma AG (DE) | 2012-01-17 | — | — | US | disclosed |
| EP-1994005-B9 | TETRAHYDRONAPHTHALINE DERIVATIVES, METHODS FOR THE PRODUCTION AND USE THEREOF AS ANTI-INFLAMMATORY AGENTS | Bayer Pharma AG (DE) | 2012-01-11 | — | — | EP | disclosed |
| EP-2041069-B1 | BENZYL AMINES, A PROCESS FOR THEIR PRODUCTION AND THEIR USE AS ANTI-INFLAMMATORY AGENTS | Bayer Pharma AG (DE) | 2011-11-30 | — | — | EP | disclosed |
| US-7999108-B2 | Benzyl amines, a process for their production and their use as anti-inflammatory agents | BAYER SCHERING PHARMA AG (DE) | 2011-08-16 | — | — | US | disclosed |
| EP-1994005-B1 | TETRAHYDRONAPHTHALINE DERIVATIVES, METHODS FOR THE PRODUCTION AND USE THEREOF AS ANTI-INFLAMMATORY AGENTS | BAYER SCHERING PHARMA AG (DE) | 2011-07-20 | — | — | EP | disclosed |
| US-7880042-B2 | antiinflammatory agents; (5 alpha ,6 alpha ,8 beta )-2-fluoro-8-methyl-5-[(2-methylquinoline-5-yl)amino]-6-(trifluoromethyl)-5,6,7,8-tetrahydronaphthalene-1,6-diol; side effect reduction | BAYER SCHERING PHARMA AG (DE) | 2011-02-01 | — | — | US | disclosed |
| EP-1670458-A1 | 1-AMINO-2-OXY-SUBSTITUTED TETRAHYDRONAPHTALENE DERIVATIVES, METHODS FOR THE PRODUCTION THEREOF, AND THEIR USE AS ANTIPHLOGISTICS | SCHERING AKTIENGESELLSCHAFT (DE) | 2006-06-21 | — | — | EP | disclosed |
| US-20060084652-A1 | Alkylidene-tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents | SCHERING AG (DE) | 2006-04-20 | — | — | US | disclosed |
| WO-2006027236-A1 | ALKYLIDENE TETRAHYDRONAPHTHALENE DERIVATIVES, METHOD FOR THEIR PRODUCTION AND THEIR USE AS ANTI-INFLAMMATORY AGENTS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2006-03-16 | — | — | WO | disclosed |
| US-20050272823-A1 | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2005-12-08 | — | — | US | disclosed |
| US-20050222154-A1 | Multiply-substituted tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2005-10-06 | — | — | US | disclosed |
| US-20050209324-A1 | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2005-09-22 | — | — | US | disclosed |
| US-20050171109-A1 | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2005-08-04 | — | — | US | disclosed |
| US-20050131226-A1 | Rearranged pentanols, a process for their production and their use as anti-inflammatory agents | SCHERING AG (DE) | 2005-06-16 | — | — | US | disclosed |
| WO-2005035518-A1 | REARRANGED PENTANOLS, A METHOD FOR THE PRODUCTION THEREOF, AND THEIR USE AS ANTIPHLOGISTICS | SCHERING AKTIENGESELLSCHAFT (DE) | 2005-04-21 | — | — | WO | disclosed |
| WO-2005034939-A1 | 1-AMINO-2-OXY-SUBSTITUTED TETRAHYDRONAPHTALENE DERIVATIVES, METHODS FOR THE PRODUCTION THEREOF, AND THEIR USE AS ANTIPHLOGISTICS | SCHERING AKTIENGESELLSCHAFT (DE) | 2005-04-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084652-A1 | Alkylidene-tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents | PTGES, PTGS1, PTGES2 | KEAP1 308/4885MEN1 4085/4885USP2 3087/4885 |
| US-20120289510-A1 | Benzyl Amines, A Process For Their Production And Their Use As Anti-Inflammtory Agents | IL1B, TNF, NFKBIA | KEAP1 481/4885MEN1 3829/4885USP2 2694/4885 |
| US-20050171109-A1 | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents | TNF, DHPS, PTGES | KEAP1 389/4885MEN1 4050/4885USP2 2993/4885 |
| US-20050222154-A1 | Multiply-substituted tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents | DHPS, TNF, IL1B | KEAP1 574/4885MEN1 1664/4885USP2 3596/4885 |
| US-20050131226-A1 | Rearranged pentanols, a process for their production and their use as anti-inflammatory agents | TNF, PTGES, PTGES2 | KEAP1 1709/4885MEN1 4337/4885USP2 2031/4885 |
| US-20050272823-A1 | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents | DHPS, TNF, PTGES | KEAP1 441/4885MEN1 2555/4885USP2 3427/4885 |
| US-20050209324-A1 | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents | TNF, DHPS, PTGES | KEAP1 389/4885MEN1 4050/4885USP2 2993/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.