Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 17/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.41 |
| ▸ | SCD | O00767 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3324035 | 1.00 | TRPV1 (0.44) | TRPV1CYP2D6TRPM8SCD | |
| SCHEMBL3322042 | 0.84 | TRPM8 (0.40) | TRPV1CYP2D6TRPM8SCD | |
| SCHEMBL3320421 | 0.84 | TRPM8 (0.40) | TRPV1CYP2D6TRPM8SCD | |
| SCHEMBL3324617 | 0.84 | TRPV1 (0.43) | TRPV1CYP2D6TRPM8 | |
| SCHEMBL3324623 | 0.84 | TRPV1 (0.43) | TRPV1CYP2D6TRPM8 | |
| SCHEMBL2317663 | 0.82 | TRPV1 (0.41) | TRPV1CYP2D6 | |
| SCHEMBL2317667 | 0.82 | TRPV1 (0.41) | TRPV1CYP2D6 | |
| SCHEMBL3323873 | 0.79 | TRPV1 (0.44) | TRPV1CYP2D6 | |
| SCHEMBL3323877 | 0.79 | TRPV1 (0.44) | TRPV1CYP2D6 | |
| SCHEMBL17112284 | 0.78 | TRPV1 (0.43) | TRPV1TRPM8SCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8609692-B2 | TRPV1 antagonists | ABBVIE INC. (US) | 2013-12-17 | — | — | US | disclosed |
| US-8604053-B2 | TRPV1 antagonists | ABBVIE INC. (US) | 2013-12-10 | — | — | US | disclosed |
| US-20100137360-A1 | TRPV1 ANTAGONISTS | ABBOTT LABORATORIES (US) | 2010-06-03 | — | — | US | disclosed |
| US-20100120789-A1 | Compound | STERIX LIMITED (GB) | 2010-05-13 | — | — | US | disclosed |
| US-20100120846-A1 | TRPV1 ANTAGONISTS | ABBOTT LABORATORIES (US) | 2010-05-13 | — | — | US | disclosed |
| US-20090042929-A1 | 11-Beta-Hydroxysteroid Dehydrogenase Inhibitors | STERIX LIMITED (GB) | 2009-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137360-A1 | TRPV1 ANTAGONISTS | TRPV1, TRPV3, TRPV2 | TRPV1 1/4885CYP2D6 878/4885TRPM8 8/4885 |
| US-20100120846-A1 | TRPV1 ANTAGONISTS | TRPV1, TRPV3, TRPV2 | TRPV1 1/4885CYP2D6 875/4885TRPM8 8/4885 |
| US-20090042929-A1 | 11-Beta-Hydroxysteroid Dehydrogenase Inhibitors | HSD3B1, HSD3B2, HSD11B1 | TRPV1 4869/4885CYP2D6 108/4885TRPM8 4621/4885 |
| US-20100120789-A1 | Compound | NR0B2, NR0B1, NR4A1 | TRPV1 3613/4885CYP2D6 228/4885TRPM8 2044/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.