SCHEMBL3327474

SCHEMBL3327474

O=c1c(-c2ccccc2)ccc2[nH]cc3ccccc3c1-2

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 2/20 0.45
MEN1 O00255 5/20 0.37
KMT2A Q03164 5/20 0.37
GPR84 Q9NQS5 2/20 0.37
KDM4E B2RXH2 2/20 0.37
ALDH1A1 P00352 2/20 0.37
DNMT1 P26358 1/20 0.37
MAPT P10636 4/20 0.36
HTT P42858 3/20 0.36
NPSR1 Q6W5P4 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
ALOX5 P09917 1/20 0.36
HPGD P15428 3/20 0.36
MAPK1 P28482 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
LMNA P02545 2/20 0.34
CSNK2A2 P19784 1/20 0.34
CSNK2B P67870 1/20 0.34
CSNK2A1 P68400 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6170258 0.78 ALDH1A1 (0.34) PARP1ALDH1A1DNMT1MAPTTDP1
SCHEMBL9039648 0.78 C1R (0.36) PARP1KDM4EDNMT1CSNK2A2CSNK2B
SCHEMBL840996 0.78 DNMT1 (0.35) PARP1DNMT1CSNK2A2CSNK2BCSNK2A1
SCHEMBL11773632 0.78 ALOX5 (0.38) PARP1MEN1KMT2AKDM4EALDH1A1
SCHEMBL5312559 0.76 PARP1 (0.33) PARP1ALDH1A1DNMT1TDP1CSNK2A2
SCHEMBL9020742 0.74 ELANE (0.32) PARP1KDM4EALDH1A1TDP1MAPK1
SCHEMBL378547 0.71 DNMT1 (0.38) PARP1MEN1KMT2AKDM4EALDH1A1
Hydrochloric Acid SCHEMBL6554454 0.70 DNMT1 (0.37) PARP1MEN1KMT2AKDM4EALDH1A1
Hydrochloric Acid SCHEMBL28299257 0.70 DNMT1 (0.37) PARP1MEN1KMT2AKDM4EALDH1A1
SCHEMBL11568940 0.69 S100A4 (0.33) PARP1KDM4EALDH1A1DNMT1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11311567-B2 Cytochrome P450 enzyme complexes and methods of treatment using the same INNOVATION HAMMER, LLC (US) 2022-04-26 US disclosed
US-11311566-B2 Cytochrome P450 enzyme complexes and methods of treatment using the same INNOVATION HAMMER, LLC (US) 2022-04-26 US disclosed
US-20210015838-A1 Cytochrome P450 Enzyme Complexes And Methods Of Treatment Using The Same INNOVATION HAMMER LLC (US) 2021-01-21 US disclosed
US-20200384008-A1 Cytochrome P450 Enzyme Complexes And Methods Of Treatment Using The Same INNOVATION HAMMER LLC (US) 2020-12-10 US disclosed
US-10786524-B2 Cytochrome P450 enzyme complexes and methods of treatment using the same INNOVATION HAMMER LLC (US) 2020-09-29 US disclosed
US-20200061096-A1 Cytochrome P450 Enzyme Complexes And Methods Of Treatment Using The Same INNOVATION HAMMER LLC (US) 2020-02-27 US disclosed
US-20170368092-A1 Cytochrome P450 Enzyme Complexes And Methods Of Treatment Using The Same INNOVATION HAMMER LLC (US) 2017-12-28 US disclosed
US-20130137655-A1 Cytochrome P450 Enzyme Complexes And Methods Of Treatment Using The Same INNOVATION HAMMER, LLC 2013-05-30 US disclosed
US-20100129890-A1 Cytochrome P450 enzyme complexes and methods of treatment using the same NONOMURA ARTHUR M 2010-05-27 US disclosed
EP-1838337-A2 CYTOCHROME P450 ENZYME COMPLEXES AND METHODS OF TREATMENT USING THE SAME Nonomura, Arthur M. (US) 2007-10-03 EP disclosed
WO-2006081014-A2 CYTOCHROME P450 ENZYME COMPLEXES AND METHODS OF TREATMENT USING THE SAME NONOMURA ARTHUR M (US) 2006-08-03 WO disclosed
US-20060140927-A1 Cytochrome P450 enzyme complexes and methods of treatment using the same NONOMURA ARTHUR M 2006-06-29 US disclosed
EP-1032262-A4 METHODS AND COMPOSITIONS FOR ENHANCING CYTOCHROME P450 IN PLANTS NONOMURA ARTHUR M (US) 2005-03-23 EP disclosed
EP-1032262-A1 METHODS AND COMPOSITIONS FOR ENHANCING CYTOCHROME P450 IN PLANTS NONOMURA, Arthur M. (US) 2000-09-06 EP disclosed
US-6020288-A PLANT GROWTH AGENT NONOMURA ARTHUR M (US) 2000-02-01 US disclosed
WO-1999012417-A1 METHODS AND COMPOSITIONS FOR ENHANCING CYTOCHROME P450 IN PLANTS NONOMURA ARTHUR M (US) 1999-03-18 WO disclosed