Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR142 | Q7Z601 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.46 |
| ▸ | GRK2 | P25098 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9179947 | 0.79 | ELOVL1 (0.60) | GPR142LMNAMAPTMEN1KMT2A | |
| SCHEMBL12678090 | 0.79 | ELOVL1 (0.60) | GPR142LMNAMAPTMEN1KMT2A | |
| SCHEMBL3339365 | 0.77 | ELOVL1 (0.51) | GPR142LMNAMAPTMEN1KMT2A | |
| SCHEMBL12890735 | 0.76 | LOXL2 (0.54) | LMNAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL73955 | 0.75 | MME (0.56) | ALDH1A1 | |
| SCHEMBL11581853 | 0.75 | MME (0.56) | ALDH1A1 | |
| SCHEMBL497336 | 0.75 | MME (0.56) | ALDH1A1 | |
| SCHEMBL4827541 | 0.75 | LMNA (0.51) | LMNAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL14106348 | 0.75 | MEN1 (0.59) | LMNAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL18215350 | 0.74 | MAPK1 (0.56) | LMNAMAPTMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8257931-B2 | Regulation of protein synthesis | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-09-04 | — | — | US | disclosed |
| US-8257931-B2 | Regulation of protein synthesis | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-09-04 | — | — | US | disclosed |
| US-8257931-B2 | Regulation of protein synthesis | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-09-04 | — | — | US | disclosed |
| US-20100144805-A1 | Regulation of protein synthesis | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-06-10 | — | — | US | disclosed |
| US-20100144805-A1 | Regulation of protein synthesis | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-06-10 | — | — | US | disclosed |
| US-20100144805-A1 | Regulation of protein synthesis | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-06-10 | — | — | US | disclosed |
| EP-1868604-A2 | REGULATION OF PROTEIN SYNTHESIS BY INHIBITION OF EIF4E-EIF4G INTERACTION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2007-12-26 | — | — | EP | disclosed |
| WO-2006078942-A2 | REGULATION OF PROTEIN SYNTHESIS BY INHIBITION OF EIF4E-EIF4G INTERACTION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2006-07-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144805-A1 | Regulation of protein synthesis | EIF4EBP1, RNMT, NCBP1 | GPR142 4239/4885LMNA 2098/4885MAPT 3352/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.