Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | DHFR | P00374 | 2/20 | 0.56 |
| ▸ | GUSB | P08236 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 4/20 | 0.47 |
| ▸ | CA2 | P00918 | 4/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3341613 | 0.91 | KIF11 (0.62) | KIF11POLBDHFRGUSBALDH1A1 | |
| SCHEMBL3341625 | 0.91 | KIF11 (0.59) | KIF11POLBDHFRGUSBALDH1A1 | |
| SCHEMBL3343668 | 0.88 | KIF11 (0.61) | KIF11POLBDHFRGUSBALDH1A1 | |
| SCHEMBL3394543 | 0.88 | KIF11 (0.74) | KIF11POLBALDH1A1SMN1; SMN2ADORA2B | |
| Monastrol SCHEMBL3168349 | 0.85 | KIF11 (0.77) | KIF11POLBDHFRGUSBALDH1A1 | |
| S-Menastrol SCHEMBL74457 | 0.85 | KIF11 (0.77) | KIF11POLBDHFRGUSBALDH1A1 | |
| SCHEMBL3335771 | 0.85 | KIF11 (0.52) | KIF11POLBDHFRGUSBALDH1A1 | |
| SCHEMBL3339245 | 0.83 | KIF11 (0.51) | KIF11POLBDHFRGUSBALDH1A1 | |
| SCHEMBL3340912 | 0.83 | KIF11 (0.55) | KIF11POLBDHFRGUSBALDH1A1 | |
| SCHEMBL14164096 | 0.82 | KIF11 (0.61) | KIF11POLBDHFRGUSBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100152206-A1 | Bicyclic Dihydropyrimidines and Uses Thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2010-06-17 | — | — | US | disclosed |
| US-20100152206-A1 | Bicyclic Dihydropyrimidines and Uses Thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2010-06-17 | — | — | US | disclosed |
| US-20100152206-A1 | Bicyclic Dihydropyrimidines and Uses Thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2010-06-17 | — | — | US | disclosed |
| WO-2010046780-A2 | ANTI VIRAL COMPOUNDS | INSTITUT PASTEUR KOREA (KR) | 2010-04-29 | — | — | WO | disclosed |
| WO-2010046780-A2 | ANTI VIRAL COMPOUNDS | INSTITUT PASTEUR KOREA (KR) | 2010-04-29 | — | — | WO | disclosed |
| WO-2006074293-A2 | BICYCLIC DIHYDROPYRIMIDINES AS EG5 INHIBITORS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2006-07-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152206-A1 | Bicyclic Dihydropyrimidines and Uses Thereof | KIF5A, KIF5C, KIF5B | KIF11 14/4885POLB 507/4885DHFR 45/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.