Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 2/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA4 | P22748 | 1/20 | 0.31 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.31 |
| ▸ | TUBB | P07437 | 1/20 | 0.31 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.31 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2439838 | 0.84 | SMN1; SMN2 (0.35) | PTGS2SMN1; SMN2TUBB1AOC3CA2 | |
| SCHEMBL9811854 | 0.82 | ALDH1A1 (0.35) | PTGS2SMN1; SMN2TUBB1AOC3ACHE | |
| SCHEMBL8097028 | 0.80 | PTGS2 (0.32) | PTGS2PDE3BPDE3ACA9CA12 | |
| SCHEMBL16094670 | 0.80 | PTGS2 (0.32) | PTGS2ACHECA9CA12CA1 | |
| SCHEMBL15063533 | 0.80 | PTGS2 (0.32) | PTGS2 | |
| SCHEMBL8479607 | 0.78 | TDP1 (0.34) | PTGS2TUBB1CA9CA12CA1 | |
| SCHEMBL7669904 | 0.74 | TUBB4A (0.57) | TUBB1AOC3TUBB4ATUBBTUBA3C | |
| SCHEMBL64882 | 0.73 | CA1 (0.42) | PTGS2SMN1; SMN2CA9CA12CA1 | |
| SCHEMBL7743958 | 0.73 | PTGS2 (0.42) | PTGS2TUBB1ACHECA9MAPT | |
| SCHEMBL77640 | 0.72 | CA9 (0.35) | PTGS2SMN1; SMN2TUBB1ACHECA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9029400-B2 | 5-oxoisoxazoles as inhibitors of lipases and phospholipases | SANOFI (FR) | 2015-05-12 | — | — | US | disclosed |
| US-20100152246-A1 | 5-Oxoisoxazoles as inhibitors of lipases and phospholipases | SANOFI-AVENTIS (FR) | 2010-06-17 | — | — | US | disclosed |
| US-6004988-A | Carboxylic acid derivatives, their preparation and their use | BASF AKTIENGESELLSCHAFT (DE) | 1999-12-21 | — | — | US | disclosed |
| EP-0707585-A1 | BICYCLIC TETRAHYDRO PYRAZOLOPYRIDINES | PFIZER INC. (US) | 1996-04-24 | — | — | EP | disclosed |
| WO-1995001980-A1 | BICYCLIC TETRAHYDRO PYRAZOLOPYRIDINES | PFIZER INC. (US) | 1995-01-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152246-A1 | 5-Oxoisoxazoles as inhibitors of lipases and phospholipases | PLAAT5, PNLIP, PLA2G5 | PTGS2 992/4885SMN1; SMN2 4352/4885TUBB1 3222/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.