Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMPR1B | O00238 | 1/20 | 0.37 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.37 |
| ▸ | CD38 | P28907 | 3/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 4/20 | 0.33 |
| ▸ | PDCD1LG2 | Q9BQ51 | 2/20 | 0.33 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 5/20 | 0.32 |
| ▸ | JAK2 | O60674 | 3/20 | 0.32 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12651164 | 0.94 | BMPR1B (0.38) | BMPR1BBMPR1ATGFBR1ACVRL1ACVR1 | |
| Trifluoroacetic Acid SCHEMBL3339192 | 0.88 | BDKRB1 (0.41) | BMPR1BBMPR1ATGFBR1ACVRL1ACVR1 | |
| Trifluoroacetic Acid SCHEMBL3340083 | 0.86 | OPRM1 (0.41) | OPRM1OPRD1OPRK1JAK1JAK2 | |
| Trifluoroacetic Acid SCHEMBL3338541 | 0.85 | FAAH (0.42) | BMPR1BBMPR1ATGFBR1ACVRL1ACVR1 | |
| SCHEMBL1787929 | 0.83 | BDKRB1 (0.41) | BMPR1BBMPR1ATGFBR1ACVRL1ACVR1 | |
| Trifluoroacetic Acid SCHEMBL16194864 | 0.81 | BDKRB1 (0.40) | BMPR1BBMPR1ATGFBR1ACVRL1ACVR1 | |
| Trifluoroacetic Acid SCHEMBL3339973 | 0.81 | BDKRB1 (0.39) | BMPR1BBMPR1ATGFBR1ACVRL1ACVR1 | |
| SCHEMBL1784811 | 0.80 | OPRM1 (0.44) | OPRM1OPRD1OPRK1JAK1JAK2 | |
| SCHEMBL12651386 | 0.80 | FAAH (0.45) | BMPR1BBMPR1ATGFBR1ACVRL1ACVR1 | |
| Trifluoroacetic Acid SCHEMBL3339087 | 0.77 | OPRM1 (0.41) | OPRM1OPRD1OPRK1CD274JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140323487-A1 | Novel Compounds As Antagonists Or Inverse Agonists At Opioid Receptors | GLAXOSMITHKLINE LLC | 2014-10-30 | — | — | US | disclosed |
| US-20100113512-A1 | METHOD OF TREATMENT USING NOVEL ANTAGONISTS OR INVERSE AGONISTS AT OPIOID RECEPTORS | IGNAR DIANE MICHELE | 2010-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113512-A1 | METHOD OF TREATMENT USING NOVEL ANTAGONISTS OR INVERSE AGONISTS AT OPIOID RECEPTORS | OPRL1, OPRD1, OPRK1 | BMPR1B 458/4885BMPR1A 453/4885TGFBR1 1808/4885 |
| US-20140323487-A1 | Novel Compounds As Antagonists Or Inverse Agonists At Opioid Receptors | OPRL1, OPRM1, OPRK1 | BMPR1B 672/4885BMPR1A 591/4885TGFBR1 817/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.