Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR5A | P47898 | 4/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 3/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3340242 | 0.99 | HTR5A (0.46) | HTR5AEPHX2NR1H4HDAC1SLC2A1 | |
| SCHEMBL12651148 | 0.95 | EPHX2 (0.49) | HTR5AEPHX2NR1H4HDAC1OPRM1 | |
| Trifluoroacetic Acid SCHEMBL3340372 | 0.94 | OPRM1 (0.44) | HTR5AEPHX2NR1H4HDAC1SLC2A1 | |
| SCHEMBL12651379 | 0.94 | RAB9A (0.49) | HTR5AEPHX2NR1H4HDAC1OPRM1 | |
| Trifluoroacetic Acid SCHEMBL3341197 | 0.92 | EPHX2 (0.52) | HTR5AEPHX2NR1H4HDAC1SLC2A1 | |
| SCHEMBL12651252 | 0.88 | F10 (0.48) | HTR5AEPHX2NR1H4HDAC1OPRM1 | |
| Trifluoroacetic Acid SCHEMBL3340186 | 0.88 | HDAC1 (0.46) | HTR5AEPHX2NR1H4HDAC1SLC2A1 | |
| SCHEMBL12651503 | 0.86 | EPHX2 (0.58) | EPHX2NR1H4HDAC1RAB9APRKD1 | |
| Trifluoroacetic Acid SCHEMBL3338278 | 0.85 | OPRM1 (0.50) | HTR5AHDAC1SLC2A1OPRM1OPRD1 | |
| Trifluoroacetic Acid SCHEMBL3341720 | 0.84 | DPP4 (0.44) | HTR5ASLC2A1OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140323487-A1 | Novel Compounds As Antagonists Or Inverse Agonists At Opioid Receptors | GLAXOSMITHKLINE LLC | 2014-10-30 | — | — | US | disclosed |
| US-20100113512-A1 | METHOD OF TREATMENT USING NOVEL ANTAGONISTS OR INVERSE AGONISTS AT OPIOID RECEPTORS | IGNAR DIANE MICHELE | 2010-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113512-A1 | METHOD OF TREATMENT USING NOVEL ANTAGONISTS OR INVERSE AGONISTS AT OPIOID RECEPTORS | OPRL1, OPRD1, OPRK1 | HTR5A 281/4885EPHX2 2604/4885NR1H4 190/4885 |
| US-20140323487-A1 | Novel Compounds As Antagonists Or Inverse Agonists At Opioid Receptors | OPRL1, OPRM1, OPRK1 | HTR5A 204/4885EPHX2 1937/4885NR1H4 228/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.