Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.52 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.52 |
| ▸ | CFD | P00746 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.46 |
| ▸ | ERN1 | O75460 | 1/20 | 0.46 |
| ▸ | CCR2 | P41597 | 1/20 | 0.46 |
| ▸ | SENP1 | Q9P0U3 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
| ▸ | PRKCG | P05129 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | FES | P07332 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | ROS1 | P08922 | 1/20 | 0.44 |
| ▸ | FER | P16591 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
| ▸ | AXL | P30530 | 1/20 | 0.44 |
| ▸ | FLT4 | P35916 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12651503 | 0.94 | EPHX2 (0.58) | EPHX2NR1H4CFDHDAC1ERN1 | |
| Trifluoroacetic Acid SCHEMBL3340242 | 0.93 | HTR5A (0.46) | EPHX2NR1H4HDAC1SLC2A1RAB9A | |
| Trifluoroacetic Acid SCHEMBL3340179 | 0.92 | HTR5A (0.45) | EPHX2NR1H4HDAC1SLC2A1PRKD1 | |
| Trifluoroacetic Acid SCHEMBL3340372 | 0.91 | OPRM1 (0.44) | EPHX2NR1H4HDAC1CCR2SLC2A1 | |
| Trifluoroacetic Acid SCHEMBL3340186 | 0.91 | HDAC1 (0.46) | EPHX2NR1H4HDAC1SLC2A1PRKD1 | |
| Trifluoroacetic Acid SCHEMBL3338278 | 0.88 | OPRM1 (0.50) | HDAC1CCR2SLC2A1PRKD1MEN1 | |
| SCHEMBL12651379 | 0.87 | RAB9A (0.49) | EPHX2NR1H4CFDHDAC1PRKD1 | |
| SCHEMBL12651148 | 0.86 | EPHX2 (0.49) | EPHX2NR1H4HDAC1PRKD1MEN1 | |
| SCHEMBL12651252 | 0.85 | F10 (0.48) | EPHX2NR1H4CFDHDAC1PRKD1 | |
| SCHEMBL12651075 | 0.83 | PRKD1 (0.49) | EPHX2NR1H4HDAC1PRKD1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140323487-A1 | Novel Compounds As Antagonists Or Inverse Agonists At Opioid Receptors | GLAXOSMITHKLINE LLC | 2014-10-30 | — | — | US | disclosed |
| US-20100113512-A1 | METHOD OF TREATMENT USING NOVEL ANTAGONISTS OR INVERSE AGONISTS AT OPIOID RECEPTORS | IGNAR DIANE MICHELE | 2010-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113512-A1 | METHOD OF TREATMENT USING NOVEL ANTAGONISTS OR INVERSE AGONISTS AT OPIOID RECEPTORS | OPRL1, OPRD1, OPRK1 | EPHX2 2604/4885NR1H4 190/4885CFD 4700/4885 |
| US-20140323487-A1 | Novel Compounds As Antagonists Or Inverse Agonists At Opioid Receptors | OPRL1, OPRM1, OPRK1 | EPHX2 1937/4885NR1H4 228/4885CFD 4628/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.