Sugi Predict

Sugi Predict / Compounds / SCHEMBL3340189

SCHEMBL3340189

SCHEMBL3340189

C=CCOc1cc(OC)ccc1C=O

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 8/20 0.65
▸ FLT3 P36888 1/20 0.53
▸ TRIM24 O15164 1/20 0.50
▸ TYR P14679 1/20 0.50
▸ TRIM33 Q9UPN9 1/20 0.50
▸ ERN1 O75460 3/20 0.46
▸ CYP1A2 P05177 5/20 0.46
▸ CYP1A1 P04798 3/20 0.46
▸ CYP1B1 Q16678 3/20 0.46
▸ MAPT P10636 3/20 0.45
▸ GAA P10253 1/20 0.45
▸ L3MBTL1 Q9Y468 1/20 0.44
▸ CYP2C19 P33261 2/20 0.44
▸ LMNA P02545 1/20 0.44
▸ CYP2C9 P11712 1/20 0.44
▸ KDM4E B2RXH2 2/20 0.43
▸ MEN1 O00255 1/20 0.42
▸ KMT2A Q03164 1/20 0.42
▸ NFE2L2 Q16236 1/20 0.41
▸ HDAC8 Q9BY41 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1520406 0.89 ALDH1A1 (0.47) ALDH1A1FLT3MAPTGAALMNA
SCHEMBL7152071 0.88 KDM4E (0.52) ALDH1A1FLT3TRIM24TYRTRIM33
SCHEMBL31432706 0.87 FLT3 (0.52) ALDH1A1FLT3CYP1A2CYP1A1CYP1B1
SCHEMBL6460287 0.82 ALDH1A1 (0.43) ALDH1A1FLT3MAPTGAAL3MBTL1
SCHEMBL6880427 0.82 ALDH1A1 (0.47) ALDH1A1FLT3TRIM24TYRTRIM33
SCHEMBL8447028 0.82 ALDH1A1 (0.71) ALDH1A1TRIM24TYRTRIM33ERN1
SCHEMBL1748666 0.82 ALDH1A1 (0.71) ALDH1A1TRIM24TYRTRIM33ERN1
SCHEMBL3209556 0.81 ALDH1A1 (0.69) ALDH1A1TRIM24TYRTRIM33ERN1
SCHEMBL10158234 0.81 ERN1 (0.40) ALDH1A1ERN1MAPTGAAL3MBTL1
Formaldehyde SCHEMBL28854145 0.80 ALDH1A1 (0.92) ALDH1A1TRIM24TYRTRIM33ERN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4741389-A1 KAT6 INHIBITOR Shanghai Qilu Pharmaceutical Research and Development Centre Ltd. (CN) 2026-05-13 — — EP disclosed
CN-119954762-A 3-Cyanoethyl substituted-4-chromanone compound and preparation method thereof 湖南科技学院 2025-05-09 — — CN disclosed
WO-2025007873-A1 KAT6 INHIBITOR 上海齐鲁制药研究中心有限公司 2025-01-09 — — WO disclosed
CN-116789626-A Preparation method of aromatic chroman-4-one compound containing amide group 湖南科技学院 2023-09-22 — — CN disclosed
CN-112110888-B Cyano-containing chroman-4-ones and synthesis method thereof 常州工程职业技术学院 2022-09-02 — — CN disclosed
CN-112110888-A Cyano-containing chroman-4-ones and synthesis method thereof 常州工程职业技术学院 2020-12-22 — — CN disclosed
US-20100144729-A1 COUMARIN DERIVATIVES NOVARTIS AG (CH) 2010-06-10 — — US disclosed
US-20090318546-A1 Chromen-2-One Derivatives NOVARTIS AG (CH) 2009-12-24 — — US disclosed
EP-2109606-A1 CHROMENE S1P1 RECEPTOR ANTAGONIST Novartis Ag (CH) 2009-10-21 — — EP disclosed
EP-2010511-A1 CHROMEN-2-ONE DERIVATIVES Novartis AG (CH) 2009-01-07 — — EP disclosed
US-6747032-B2 DOUBLE ALPHA 2/5-HT 2C ANTAGONISTS USED TO TREAT DEPRESSION, IMPULSIVE BEHAVIOUR DISORDERS, ANXIETY, SCHIZOPHRENIA, PARKINSON'S DISEASE, COGNITIVE DISORDERS AND DISORDERS INVOLVING SEXUAL FUNCTION, SLEEP AND EATING LES LABORATOIRES SERVIER (FR) 2004-06-08 — — US disclosed
US-20030087916-A1 Pyrimidin-4-one compounds LES LABORATOIRES SERVIER (FR) 2003-05-08 — — US disclosed
CN-1381456-A Pyrimidine-4-keto compound, its preparation method and medicine composition containing them SIRVIR LAB (FR) 2002-11-27 — — CN disclosed
EP-1256583-A1 Pyrimidine-4-one derivatives, process for their preparation and pharmaceutical compositions containing them Les Laboratoires Servier (FR) 2002-11-13 — — EP disclosed
US-6017916-A Nonpeptide endothelin antagonists I WARNER-LAMBERT COMPANY (US) 2000-01-25 — — US disclosed
US-5691373-A TREATING SUBARACHNOID HEMORRHAGE WARNER-LAMBERT COMPANY (US) 1997-11-25 — — US disclosed
EP-0714391-A1 SUBSTITUTED 2(5H)FURANONE, 2(5H)THIOPHENONE AND 2(5H)PYRROLONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ENDOTHELIN ANTAGONISTS WARNER-LAMBERT COMPANY (US) 1996-06-05 — — EP disclosed
WO-1995005376-A1 SUBSTITUTED 2(5H)FURANONE, 2(5H)THIOPHENONE AND 2(5H)PYRROLONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ENDOTHELIN ANTAGONISTS WARNER-LAMBERT COMPANY (US) 1995-02-23 — — WO disclosed
US-4603139-A 2-PHENYL-1H-IMIDAZOL(4,5-C)PYRIDINES, ANTICXOAGULANTS, CARDIOVASCULAR DISORDERS BURROUGHS WELLCOME CO. 1986-07-29 — — US disclosed
EP-0079083-A1 New imidazo[4,5-c]pyridine derivatives, processes for their preparation and pharmaceutical formulations containing such compounds MERCK PATENT GmbH (DE) 1983-05-18 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090318546-A1 Chromen-2-One Derivatives CYP1A2, CYP4B1, CYP1B1 ALDH1A1 330/4885FLT3 363/4885TRIM24 2310/4885
US-20100144729-A1 COUMARIN DERIVATIVES F3, CYP3A7, CYP3A4 ALDH1A1 60/4885FLT3 81/4885TRIM24 2528/4885
US-20030087916-A1 Pyrimidin-4-one compounds HTR2C, HTR1A, HTR4 ALDH1A1 1216/4885FLT3 989/4885TRIM24 3991/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.