SCHEMBL3344740

SCHEMBL3344740

COC(=O)COc1cc(Cl)cc2c1c(C)c(Cc1ccc(Cl)cc1)c(=O)n2C

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.39
HPGD P15428 3/20 0.39
KDM4E B2RXH2 3/20 0.39
HSD17B10 Q99714 2/20 0.39
GAA P10253 1/20 0.39
LMNA P02545 2/20 0.38
ADORA2A P29274 1/20 0.38
ADORA2B P29275 1/20 0.38
P2RX3 P56373 1/20 0.37
PTGDR Q13258 1/20 0.37
PTGDR2 Q9Y5Y4 1/20 0.37
PTGS2 P35354 1/20 0.37
PKM P14618 1/20 0.36
TRPC5 Q9UL62 1/20 0.36
PLA2G2A P14555 1/20 0.36
PPARG P37231 1/20 0.35
PDE3B Q13370 1/20 0.35
PDE3A Q14432 1/20 0.35
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3345067 0.90 PPARG (0.42) PTGDR2PKMTRPC5PPARGTSHR
SCHEMBL3345108 0.85 ALDH1A1 (0.43) ALDH1A1HPGDKDM4EHSD17B10GAA
SCHEMBL3346109 0.83 ALDH1A1 (0.44) ALDH1A1HPGDKDM4EHSD17B10GAA
SCHEMBL3345142 0.83 ALDH1A1 (0.45) ALDH1A1HPGDKDM4EHSD17B10GAA
SCHEMBL3345066 0.83 TDP1 (0.43) ALDH1A1HPGDKDM4EHSD17B10PTGDR2
SCHEMBL3344798 0.83 HPGD (0.43) ALDH1A1HPGDKDM4EHSD17B10GAA
SCHEMBL3348099 0.83 HPGD (0.41) ALDH1A1HPGDKDM4EHSD17B10P2RX3
SCHEMBL3349038 0.82 PTGS2 (0.37) ALDH1A1KDM4ELMNAADORA2AADORA2B
SCHEMBL3349098 0.82 ALDH1A1 (0.44) ALDH1A1HPGDKDM4EHSD17B10GAA
SCHEMBL3344721 0.81 P2RX3 (0.42) ALDH1A1HPGDKDM4EHSD17B10GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4096133-A Method for quaternizing polymers of water-soluble aminovinyl monomers THE DOW CHEMICAL COMPANY (US) 1978-06-20 US claimed
US-4024328-A Method for alkylating aminomethylacrylamide polymers THE DOW CHEMICAL COMPANY (US) 1977-05-17 US claimed
WO-2010040813-A1 COSMETIC COMPOSITION CONTAINING AN AMPHIPHILIC ZWITTERIONIC COPOLYMER RHODIA OPERATIONS (FR) 2010-04-15 WO disclosed
WO-2010040989-A1 QUINOLIN-2-ONE COMPOUNDS ARGENTA ORAL THERAPEUTICS LIMITED (GB) 2010-04-15 WO disclosed
EP-1046957-B1 Photosensitive resin composition JSR CORP (JP) 2004-07-28 EP disclosed
US-6280905-B1 LIGHT SENSITIVE ELEMENT WITH COPOLYMER OF ALAPHATIC CONJUGATED DIENE AND UNSATURATED AMINO COMPOUNDS JSR CORPORATION (JP) 2001-08-28 US disclosed
EP-1046957-A1 Photosensitive resin composition JSR Corporation (JP) 2000-10-25 EP disclosed