Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | TRPC5 | Q9UL62 | 2/20 | 0.36 |
| ▸ | PPARG | P37231 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3344735 | 0.90 | PPARG (0.42) | TRPC5PPARGKMT2AMEN1KDM4E | |
| SCHEMBL3344740 | 0.82 | ALDH1A1 (0.39) | PTGS2TRPC5PPARGKMT2AMEN1 | |
| SCHEMBL3351508 | 0.79 | PTGS2 (0.37) | PTGS2KMT2AMEN1KDM4EMAPK1 | |
| SCHEMBL3344721 | 0.77 | P2RX3 (0.42) | PTGS2KDM4EMAPK1ALOX15ALDH1A1 | |
| SCHEMBL3346109 | 0.76 | ALDH1A1 (0.44) | KDM4EMAPK1ALDH1A1L3MBTL1P2RX3 | |
| SCHEMBL3345108 | 0.75 | ALDH1A1 (0.43) | PTGS2TRPC5KMT2AMEN1KDM4E | |
| SCHEMBL3346140 | 0.75 | PTGDR2 (0.38) | PTGS2TRPC5KMT2AMEN1KDM4E | |
| SCHEMBL3344729 | 0.74 | DDB1 (0.41) | TRPC5KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL3345407 | 0.73 | PLA2G2A (0.45) | PPARGKDM4EALDH1A1 | |
| SCHEMBL3345008 | 0.73 | P2RX3 (0.43) | TRPC5KMT2AMEN1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010040989-A1 | QUINOLIN-2-ONE COMPOUNDS | ARGENTA ORAL THERAPEUTICS LIMITED (GB) | 2010-04-15 | — | — | WO | disclosed |