Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.38 |
| ▸ | WDR5 | P61964 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.37 |
| ▸ | THRA | P10827 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3345051 | 0.91 | P2RX3 (0.42) | TDP1TSHRRORCPPARGPPARD | |
| SCHEMBL3345008 | 0.90 | P2RX3 (0.43) | TDP1TSHRRORCP2RX3MAPT | |
| SCHEMBL13423755 | 0.89 | PTGDR2 (0.44) | TDP1TSHRRORCPTGDR2 | |
| SCHEMBL3345546 | 0.84 | PTGDR2 (0.50) | RORCPTGDR2 | |
| SCHEMBL3345407 | 0.84 | PLA2G2A (0.45) | PPARGPTGDR2 | |
| SCHEMBL3345067 | 0.82 | PPARG (0.42) | TDP1TSHRRORCPPARGPPARD | |
| SCHEMBL3344735 | 0.82 | PPARG (0.42) | TDP1TSHRRORCPPARGPPARD | |
| SCHEMBL3344721 | 0.82 | P2RX3 (0.42) | P2RX3MAPTPTGDR2LMNA | |
| SCHEMBL3345066 | 0.81 | TDP1 (0.43) | TDP1TSHRRORCPPARGPPARD | |
| SCHEMBL3351438 | 0.81 | TSHR (0.41) | TSHRRORCPTGDR2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010040989-A1 | QUINOLIN-2-ONE COMPOUNDS | ARGENTA ORAL THERAPEUTICS LIMITED (GB) | 2010-04-15 | — | — | WO | claimed |
| WO-2010040989-A1 | QUINOLIN-2-ONE COMPOUNDS | ARGENTA ORAL THERAPEUTICS LIMITED (GB) | 2010-04-15 | — | — | WO | disclosed |
| WO-2010040989-A1 | QUINOLIN-2-ONE COMPOUNDS | ARGENTA ORAL THERAPEUTICS LIMITED (GB) | 2010-04-15 | — | — | WO | disclosed |