Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 15/20 | 0.45 |
| ▸ | PLA2G1B | P04054 | 5/20 | 0.43 |
| ▸ | PLA2G10 | O15496 | 2/20 | 0.42 |
| ▸ | PLA2G5 | P39877 | 2/20 | 0.42 |
| ▸ | PLA2G2E | Q9NZK7 | 2/20 | 0.42 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PLA2G6 | O60733 | 1/20 | 0.39 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.39 |
| ▸ | PLA2G12B | Q9BX93 | 1/20 | 0.39 |
| ▸ | PLA2G12A | Q9BZM1 | 1/20 | 0.39 |
| ▸ | PLA2G2F | Q9BZM2 | 1/20 | 0.39 |
| ▸ | PLA2G3 | Q9NZ20 | 1/20 | 0.39 |
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3345067 | 0.88 | PPARG (0.42) | PPARGPTGDR2 | |
| SCHEMBL3344729 | 0.87 | DDB1 (0.41) | PLA2G2AKDM4EALDH1A1HPGD | |
| SCHEMBL3345066 | 0.87 | TDP1 (0.43) | PLA2G2APLA2G1BPLA2G10PLA2G5PLA2G2E | |
| SCHEMBL3345372 | 0.84 | TDP1 (0.44) | PPARGPTGDR2 | |
| SCHEMBL3345051 | 0.83 | P2RX3 (0.42) | PPARGPTGDR2 | |
| SCHEMBL3344735 | 0.83 | PPARG (0.42) | PPARGKDM4EALDH1A1HPGD | |
| SCHEMBL3348093 | 0.80 | PLA2G2A (0.45) | PLA2G2APLA2G1BPLA2G10PLA2G5PLA2G2E | |
| SCHEMBL3344022 | 0.79 | PLA2G1B (0.49) | PLA2G2APLA2G1BPLA2G10PLA2G5PLA2G2E | |
| SCHEMBL3346068 | 0.78 | TDP1 (0.43) | PLA2G2APLA2G1BPLA2G10PLA2G5PLA2G2E | |
| SCHEMBL3346049 | 0.78 | PLA2G2A (0.41) | PLA2G2APLA2G1BPLA2G10PLA2G5PLA2G2E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010040989-A1 | QUINOLIN-2-ONE COMPOUNDS | ARGENTA ORAL THERAPEUTICS LIMITED (GB) | 2010-04-15 | — | — | WO | claimed |
| WO-2010040989-A1 | QUINOLIN-2-ONE COMPOUNDS | ARGENTA ORAL THERAPEUTICS LIMITED (GB) | 2010-04-15 | — | — | WO | disclosed |
| WO-2010040989-A1 | QUINOLIN-2-ONE COMPOUNDS | ARGENTA ORAL THERAPEUTICS LIMITED (GB) | 2010-04-15 | — | — | WO | disclosed |