Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 4/20 | 0.42 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | THRA | P10827 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 2/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3349038 | 0.90 | PTGS2 (0.37) | PPARGTRPC5KMT2AKDM4EALDH1A1 | |
| SCHEMBL3345407 | 0.83 | PLA2G2A (0.45) | PPARGKDM4EALDH1A1HPGD | |
| SCHEMBL3345372 | 0.82 | TDP1 (0.44) | PPARGTRPC5THRATHRBRORC | |
| SCHEMBL3345067 | 0.81 | PPARG (0.42) | PPARGTRPC5THRATHRBRORC | |
| SCHEMBL3345066 | 0.80 | TDP1 (0.43) | PPARGTRPC5THRATHRBRORC | |
| SCHEMBL3345051 | 0.77 | P2RX3 (0.42) | PPARGTRPC5RORCPPARDTDP1 | |
| SCHEMBL3346104 | 0.75 | PLA2G10 (0.41) | THRATHRBRORCTDP1TSHR | |
| SCHEMBL3346068 | 0.74 | TDP1 (0.43) | PPARGTRPC5KMT2ATHRATHRB | |
| SCHEMBL3345008 | 0.73 | P2RX3 (0.43) | TRPC5KMT2ARORCTDP1TSHR | |
| SCHEMBL3348106 | 0.72 | PTGDR2 (0.49) | TRPC5KMT2ATSHRKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010040989-A1 | QUINOLIN-2-ONE COMPOUNDS | ARGENTA ORAL THERAPEUTICS LIMITED (GB) | 2010-04-15 | — | — | WO | disclosed |
| WO-2010040989-A1 | QUINOLIN-2-ONE COMPOUNDS | ARGENTA ORAL THERAPEUTICS LIMITED (GB) | 2010-04-15 | — | — | WO | disclosed |