SCHEMBL334556

SCHEMBL334556

COc1ccccc1[C@@H](C)N

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 4/20 0.55
CA2 P00918 4/20 0.55
CA7 P43166 2/20 0.55
CA9 Q16790 2/20 0.55
CA12 O43570 1/20 0.55
CA4 P22748 1/20 0.55
CA14 Q9ULX7 1/20 0.55
ACHE P22303 1/20 0.52
ALDH1A1 P00352 2/20 0.50
ADRA2B P18089 1/20 0.50
PTGS1 P23219 1/20 0.50
TDP1 Q9NUW8 1/20 0.50
IDO1 P14902 1/20 0.50
TDO2 P48775 1/20 0.50
CYP2D6 P10635 2/20 0.47
ADRA2A P08913 1/20 0.47
ADRA1A P35348 1/20 0.47
MAPK1 P28482 2/20 0.46
KMT2A Q03164 2/20 0.46
MEN1 O00255 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL334379 1.00 CA1 (0.55) CA1CA2CA7CA9CA12
SCHEMBL29471011 1.00 CA1 (0.55) CA1CA2CA7CA9CA12
SCHEMBL1257092 1.00 CA1 (0.55) CA1CA2CA7CA9CA12
SCHEMBL21377269 1.00 CA1 (0.55) CA1CA2CA7CA9CA12
SCHEMBL29705638 1.00 CA1 (0.55) CA1CA2CA7CA9CA12
Hydrochloric Acid SCHEMBL20746349 0.98 IDO1 (0.53) CA1CA2CA7CA9CA12
Hydrochloric Acid SCHEMBL28055201 0.98 IDO1 (0.53) CA1CA2CA7CA9CA12
Iodide SCHEMBL28805507 0.98 CA1 (0.52) CA1CA2CA7CA9CA12
Hydrochloric Acid SCHEMBL1168978 0.98 IDO1 (0.53) CA1CA2CA7CA9CA12
SCHEMBL19668658 0.90 CA1 (0.50) CA1CA2CA7CA9CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 111 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8084630-B2 Process for the synthesis of ramelteon and its intermediates TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) 2011-12-27 US claimed
US-20090281176-A1 PROCESS FOR THE SYNTHESIS OF RAMELTEON AND ITS INTERMEDIATES TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) 2009-11-12 US claimed
EP-2098519-A1 Process for the synthesis of ramelteon and its intermediates Teva Pharmaceutical Industries Ltd. (IL) 2009-09-09 EP claimed
US-20090069581-A1 PROCESS FOR THE SYNTHESIS OF RAMELTEON AND ITS INTERMEDIATES TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) 2009-03-12 US claimed
US-12428416-B2 ERK inhibitors and uses thereof CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2025-09-30 US disclosed
US-20250135005-A1 PROCESSES FOR PREPARING FUNCTIONALIZED CYCLOOCTENES TAMBO INC (US) 2025-05-01 US disclosed
US-20250066364-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS BIAL R&D INVEST S A (PT) 2025-02-27 US disclosed
US-12194100-B2 Processes for preparing functionalized cyclooctenes TAMBO, INC. (US) 2025-01-14 US disclosed
US-20240368136-A1 BENZOLACTAM COMPOUNDS AS PROTEIN KINASE INHIBITORS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2024-11-07 US disclosed
EP-4406616-A2 SUBSTITUTED PYRAZOLO(1,5-A)PYRIMIDINES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS Bial-R&D Investments, S.A. (PT) 2024-07-31 EP disclosed
US-12043602-B2 Fendiline derivatives THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2024-07-23 US disclosed
EP-3365334-B1 BENZOLACTAM COMPOUNDS AS PROTEIN KINASE INHIBITORS OTSUKA PHARMA CO LTD (JP) 2024-07-17 EP disclosed
EP-1985620-A1 10a-AZALIDE COMPOUND TAISHO PHARMACEUTICAL CO., LTD (JP) 2008-10-29 EP disclosed
WO-2008037626-A1 QUINOLINE DERIVATIVES WITH 5-HT-BINDING PROPERTIES F. HOFFMANN-LA ROCHE AG (CH) 2008-04-03 WO disclosed
US-20080081907-A1 2-AMINOQUINOLINE DERIVATIVES HOFFMANN-LA ROCHE INC. 2008-04-03 US disclosed
US-20060235033-A1 Quinoline derivatives and quinazoline derivatives inhibiting autophosphorylation of macrophage colony stimulating factor receptor KIRIN BEER KABUSHIKI KAISHA (JP) 2006-10-19 US disclosed
CN-1262535-C Method ofr synthesizing S-(1)-2.2 dimethylcyclopropane formamide UNIV ZHEJIANG (CN) 2006-07-05 CN disclosed
EP-1535910-A1 QUINOLINE DERIVATIVES AND QUINAZOLINE DERIVATIVES INHIBITING AUTOPHOSPHORYLATION OF MACROPHAGE COLONY STIMULATING FACTOR RECEPTOR KIRIN BEER KABUSHIKI KAISHA (JP) 2005-06-01 EP disclosed
CN-1562962-A Method ofr synthesizing S-(1)-2.2 dimethylcyclopropane formamide UNIV ZHEJIANG (CN) 2005-01-12 CN disclosed
US-5300437-A Using omega-amino acid transaminase CELGENE CORPORATION (US) 1994-04-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090281176-A1 PROCESS FOR THE SYNTHESIS OF RAMELTEON AND ITS INTERMEDIATES CYP2B6, UGT1A6, CYP2A6 CA1 3955/4885CA2 3084/4885CA7 2028/4885
US-12194100-B2 Processes for preparing functionalized cyclooctenes PPOX, SCO2, CYCS CA1 2904/4885CA2 4762/4885CA7 3378/4885
US-12043602-B2 Fendiline derivatives CYP11B2, CYP3A7, CYP4F2 CA1 4770/4885CA2 4359/4885CA7 3116/4885
US-20240368136-A1 BENZOLACTAM COMPOUNDS AS PROTEIN KINASE INHIBITORS MAPK1, ALK, MAP3K1 CA1 3779/4885CA2 1838/4885CA7 3566/4885
US-20080081907-A1 2-AMINOQUINOLINE DERIVATIVES AR, ADRA2C, RCC2 CA1 4591/4885CA2 1906/4885CA7 3775/4885
US-20060235033-A1 Quinoline derivatives and quinazoline derivatives inhibiting autophosphorylation of macrophage colony stimulating factor receptor CSF3R, CSF1R, MSR1 CA1 4577/4885CA2 2699/4885CA7 2548/4885
US-20250135005-A1 PROCESSES FOR PREPARING FUNCTIONALIZED CYCLOOCTENES PPOX, SCO2, CYCS CA1 2904/4885CA2 4762/4885CA7 3378/4885
US-12428416-B2 ERK inhibitors and uses thereof MAPKAPK2, MAPK3, MAP4K2 CA1 4317/4885CA2 4021/4885CA7 4598/4885
US-20090069581-A1 PROCESS FOR THE SYNTHESIS OF RAMELTEON AND ITS INTERMEDIATES CYP2B6, UGT1A6, CYP2A6 CA1 2650/4885CA2 1963/4885CA7 1770/4885
US-20250066364-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS PARK7, PNP, GAA CA1 4823/4885CA2 4792/4885CA7 4098/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.