SCHEMBL33461

SCHEMBL33461

C=CC(=O)NC(C)(C)C(=O)N1CC1

nearest known ligand 0.43

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43
ALDH1A1 P00352 2/20 0.37
CYP3A4 P08684 1/20 0.37
CYP2C9 P11712 1/20 0.37
CYP2C19 P33261 1/20 0.37
TGM2 P21980 10/20 0.34
F13A1 P00488 8/20 0.34
TGM1 P22735 8/20 0.34
TSHR P16473 2/20 0.33
TGM3 Q08188 1/20 0.32
MAPK1 P28482 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
POLB P06746 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL33466 0.77 MEN1 (0.37) MEN1KMT2AALDH1A1CYP3A4CYP2C9
SCHEMBL3116054 0.74 ALDH1A1 (0.43) MEN1KMT2AALDH1A1CYP3A4CYP2C9
SCHEMBL1420537 0.73 ALDH1A1 (0.46) MEN1KMT2AALDH1A1CYP3A4CYP2C9
SCHEMBL379428 0.73 ALDH1A1 (0.42) MEN1KMT2AALDH1A1CYP3A4CYP2C9
SCHEMBL1420931 0.71 ALDH1A1 (0.41) MEN1KMT2AALDH1A1CYP3A4CYP2C9
SCHEMBL27640713 0.71 ALDH1A1 (0.44) MEN1KMT2AALDH1A1CYP3A4CYP2C9
SCHEMBL12264424 0.69 KMT2A (0.42) MEN1KMT2AALDH1A1MAPK1
SCHEMBL4314501 0.69 ALDH1A1 (0.43) MEN1KMT2AALDH1A1CYP3A4CYP2C9
SCHEMBL26478897 0.69 ALDH1A1 (0.40) MEN1KMT2AALDH1A1CYP3A4CYP2C9
SCHEMBL7101115 0.69 ALDH1A1 (0.46) MEN1KMT2AALDH1A1CYP3A4CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10479848-B2 Addition-fragmentation oligomers 3M INNOVATIVE PROPERTIES COMPANY (US) 2019-11-19 US disclosed
US-10370322-B2 Addition-fragmentation agents 3M INNOVATIVE PROPERTIES COMPANY (US) 2019-08-06 US disclosed
US-20180044448-A1 ADDITION-FRAGMENTATION OLIGOMERS 3M INNOVATIVE PROPERTIES COMPANY 2018-02-15 US disclosed
US-20180044448-A1 ADDITION-FRAGMENTATION OLIGOMERS 3M INNOVATIVE PROPERTIES COMPANY 2018-02-15 US disclosed
US-20170210693-A1 ADDITION-FRAGMENTATION AGENTS SOLVENTUM INTELLECTUAL PROPERTIES COMPANY 2017-07-27 US disclosed
US-20170210693-A1 ADDITION-FRAGMENTATION AGENTS SOLVENTUM INTELLECTUAL PROPERTIES COMPANY 2017-07-27 US disclosed
US-9463146-B2 Addition-fragmentation oligomers 3M INNOVATIVE PROPERTIES COMPANY (US) 2016-10-11 US disclosed
US-9463146-B2 Addition-fragmentation oligomers 3M INNOVATIVE PROPERTIES COMPANY (US) 2016-10-11 US disclosed
US-9403966-B2 Addition-fragmentation agents 3M INNOVATIVE PROPERTIES COMPANY (US) 2016-08-02 US disclosed
US-20150328086-A1 ADDITION-FRAGMENTATION OLIGOMERS 3M INNOVATIVE PROPERTIES COMPANY (US) 2015-11-19 US disclosed
US-20150328086-A1 ADDITION-FRAGMENTATION OLIGOMERS 3M INNOVATIVE PROPERTIES COMPANY (US) 2015-11-19 US disclosed
US-20150203658-A1 ADDITION-FRAGMENTATION AGENTS SOLVENTUM INTELLECTUAL PROPERTIES COMPANY 2015-07-23 US disclosed
US-20130053508-A1 ACRYLIC PRESSURE-SENSITIVE ADHESIVES WITH ACYLAZIRIDINE CROSSLINKING AGENTS 3M INNOVATIVE PROPERTIES COMPANY (US) 2013-02-28 US disclosed
US-8349962-B2 Acrylic pressure-sensitive adhesives with acylaziridine crosslinking agents 3M INNOVATIVE PROPERTIES COMPANY (US) 2013-01-08 US disclosed
WO-2012112304-A1 ADDITION-FRAGMENTATION AGENTS 3M INNOVATIVE PROPERTIES COMPANY (US) 2012-08-23 WO disclosed
US-20120208965-A1 ADDITION-FRAGMENTATION AGENTS 3M INNOVATIVE PROPERTIES COMPANY 2012-08-16 US disclosed
US-20120208965-A1 ADDITION-FRAGMENTATION AGENTS 3M INNOVATIVE PROPERTIES COMPANY 2012-08-16 US disclosed
US-20120028043-A1 ACRYLIC PRESSURE-SENSITIVE ADHESIVES WITH ACYLAZIRIDINE CROSSLINKING AGENTS 3M INNOVATIVE PROPERTIES COMPANY 2012-02-02 US disclosed
US-8067504-B2 Acrylic pressure-sensitive adhesives with acylaziridine crosslinking agents 3M INNOVATIVE PROPERTIES COMPANY (US) 2011-11-29 US disclosed
US-20110054115-A1 ACRYLIC PRESSURE-SENSITIVE ADHESIVES WITH ACYLAZIRIDINE CROSSLINKING AGENTS 3M INNOVATIVE PROPERTIES COMPANY 2011-03-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10479848-B2 Addition-fragmentation oligomers ECPAS, ITGA8, NBAS MEN1 4634/4885KMT2A 2118/4885ALDH1A1 2212/4885
US-10370322-B2 Addition-fragmentation agents NR4A1, PARP14, MTX1 MEN1 183/4885KMT2A 2178/4885ALDH1A1 3630/4885
US-20110054115-A1 ACRYLIC PRESSURE-SENSITIVE ADHESIVES WITH ACYLAZIRIDINE CROSSLINKING AGENTS AAAS, PTK2, MDN1 MEN1 981/4885KMT2A 265/4885ALDH1A1 492/4885
US-20180044448-A1 ADDITION-FRAGMENTATION OLIGOMERS ECPAS, ITGA8, NBAS MEN1 4634/4885KMT2A 2118/4885ALDH1A1 2212/4885
US-20150328086-A1 ADDITION-FRAGMENTATION OLIGOMERS FGB, ZYX, APBA1 MEN1 1855/4885KMT2A 4097/4885ALDH1A1 1881/4885
US-20120208965-A1 ADDITION-FRAGMENTATION AGENTS NR4A1, PARP14, MTX1 MEN1 183/4885KMT2A 2178/4885ALDH1A1 3630/4885
US-20170210693-A1 ADDITION-FRAGMENTATION AGENTS NR4A1, PARP14, MTX1 MEN1 183/4885KMT2A 2178/4885ALDH1A1 3630/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.