Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.56 |
| ▸ | KCNK3 | O14649 | 6/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 8/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 8/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 8/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 8/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 8/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 8/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3353012 | 0.84 | KCNH2 (0.59) | KCNH2 | |
| SCHEMBL3415190 | 0.76 | KCNH2 (0.59) | KCNH2KCNK3CHRNA7 | |
| SCHEMBL3346435 | 0.76 | KCNH2 (0.58) | KCNH2 | |
| SCHEMBL3348192 | 0.75 | KCNH2 (0.57) | KCNH2CHRNA7 | |
| SCHEMBL3346321 | 0.73 | KCNH2 (0.77) | KCNH2CHRNA7 | |
| SCHEMBL3353295 | 0.72 | GPR88 (0.52) | KCNH2 | |
| SCHEMBL3347928 | 0.72 | KCNH2 (0.53) | KCNH2 | |
| SCHEMBL3346204 | 0.71 | KCNH2 (0.54) | KCNH2 | |
| SCHEMBL3345898 | 0.71 | KCNH2 (0.54) | KCNH2 | |
| SCHEMBL3350867 | 0.71 | KCNH2 (0.52) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | claimed |