Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
| ▸ | MC4R | P32245 | 2/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.44 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | FPR3 | P25089 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346450 | 0.85 | FPR3 (0.48) | MC4RALOX5APRAB9AHTTHSD11B1 | |
| SCHEMBL3346386 | 0.80 | TAAR1 (0.48) | KCNH2MC4RRAB9ANPC1KDM4E | |
| SCHEMBL3346452 | 0.78 | KCNH2 (0.48) | KCNH2MC4RKMT2A | |
| SCHEMBL3348201 | 0.76 | CNR1 (0.54) | MC4RALOX5APRAB9AHTTHSD11B1 | |
| SCHEMBL13365135 | 0.74 | KCNH2 (0.57) | KCNH2SCN9A | |
| SCHEMBL3346554 | 0.72 | KCNH2 (0.48) | KCNH2MC4R | |
| Hydrochloric Acid SCHEMBL30585928 | 0.72 | HSD11B1 (0.54) | ALOX5APRAB9ANPC1HSD11B1KDM4E | |
| Hydrochloric Acid SCHEMBL21640657 | 0.72 | HSD11B1 (0.54) | ALOX5APRAB9ANPC1HSD11B1KDM4E | |
| SCHEMBL3349714 | 0.72 | MC4R (0.57) | MC4RRAB9ANPC1L3MBTL1ALDH1A1 | |
| SCHEMBL3346548 | 0.71 | GPBAR1 (0.39) | MC4RRAB9ANPC1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | claimed |