Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.39 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MC4R | P32245 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | FPR3 | P25089 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3350852 | 0.88 | MC4R (0.37) | TRPM5MC4RROCK2FPR3 | |
| SCHEMBL3347825 | 0.86 | GPBAR1 (0.43) | GPBAR1MC4RROCK2 | |
| SCHEMBL3346450 | 0.85 | FPR3 (0.48) | RAB9AMC4RKDM4EALDH1A1ROCK2 | |
| SCHEMBL3346663 | 0.83 | KCNH2 (0.41) | GPBAR1MC4RKDM4EMEN1KMT2A | |
| SCHEMBL3349714 | 0.82 | MC4R (0.57) | NPC1RAB9AMC4RALDH1A1LMNA | |
| SCHEMBL3350808 | 0.81 | TAAR1 (0.53) | NPC1RAB9AMC4RKDM4EMEN1 | |
| SCHEMBL3346544 | 0.79 | TRPM5 (0.38) | TRPM5ROCK2MAPK1 | |
| SCHEMBL3346695 | 0.79 | CNR1 (0.50) | MC4RALDH1A1ROCK2TAAR1GLA | |
| SCHEMBL3350885 | 0.78 | TAAR1 (0.47) | GPBAR1NPC1RAB9AMC4RKDM4E | |
| SCHEMBL21036525 | 0.72 | PTK2 (0.36) | TRPM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | claimed |