Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346986 | 0.87 | GAA (0.39) | HPGDGAAALDH1A1MEN1KMT2A | |
| SCHEMBL3347067 | 0.78 | MEN1 (0.35) | HPGDGAAALDH1A1MEN1KMT2A | |
| SCHEMBL9905007 | 0.76 | KEAP1 (0.62) | GAAALDH1A1MEN1KMT2AADRA2C | |
| SCHEMBL15653140 | 0.73 | MAPT (0.67) | GAAALDH1A1MEN1KMT2ADRD2 | |
| SCHEMBL3312656 | 0.73 | ALDH1A1 (0.72) | GAAALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL1194044 | 0.73 | DRD2 (0.61) | DRD2DRD3DRD4 | |
| SCHEMBL1193917 | 0.72 | DRD2 (0.64) | HPGDALDH1A1TSHRMAPK1DRD2 | |
| SCHEMBL3346311 | 0.71 | KDM4E (0.36) | HPGDGAAALDH1A1TSHRMAPK1 | |
| SCHEMBL15651320 | 0.71 | LGMN (0.49) | HPGDGAAALDH1A1MEN1KMT2A | |
| SCHEMBL4572947 | 0.71 | ADRA2C (0.56) | GAAALDH1A1ADRA2CTSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010049731-A1 | PYRAZOLO- AND IMIDAZOPYRIDINYLPYRIMIDINEAMINES AS IGF-1R TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-05-06 | — | — | WO | disclosed |