Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3345855 | 0.82 | KDM4E (0.33) | ALDH1A1L3MBTL1KDM4EMAPK1HTT | |
| SCHEMBL3347609 | 0.81 | GRM5 (0.33) | GRM5 | |
| SCHEMBL3345928 | 0.81 | GRM5 (0.36) | GRM5ALDH1A1L3MBTL1KDM4EMAPK1 | |
| SCHEMBL3345927 | 0.80 | GRM5 (0.36) | GRM5CYP1A2CYP2D6 | |
| SCHEMBL3347664 | 0.80 | GRM5 (0.37) | GRM5ALDH1A1L3MBTL1KDM4EMAPK1 | |
| SCHEMBL3346856 | 0.79 | GRM5 (0.52) | GRM5ALDH1A1L3MBTL1KDM4EMAPK1 | |
| SCHEMBL3351706 | 0.79 | KDM4E (0.34) | GRM5ALDH1A1L3MBTL1KDM4EMAPK1 | |
| SCHEMBL3346517 | 0.79 | GRM5 (0.34) | GRM5ALDH1A1L3MBTL1KDM4EMAPK1 | |
| SCHEMBL3347641 | 0.78 | GRM5 (0.38) | GRM5ALDH1A1L3MBTL1KDM4EMAPK1 | |
| SCHEMBL3347055 | 0.77 | GRM5 (0.51) | GRM5ALDH1A1L3MBTL1KDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | claimed |
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |