Sugi Predict

Sugi Predict / Compounds / SCHEMBL334753

SCHEMBL334753

SCHEMBL334753

CCn1c2cc[c]cc2c2ccccc21

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 4/20 0.55
▸ KDM4E B2RXH2 8/20 0.51
▸ MAPT P10636 6/20 0.51
▸ MEN1 O00255 4/20 0.51
▸ KMT2A Q03164 4/20 0.51
▸ HTT P42858 4/20 0.51
▸ MAPK1 P28482 3/20 0.51
▸ HSD17B10 Q99714 3/20 0.51
▸ TDP1 Q9NUW8 2/20 0.51
▸ HPGD P15428 2/20 0.51
▸ HBB P68871 1/20 0.51
▸ LMNA P02545 5/20 0.47
▸ POLB P06746 2/20 0.47
▸ CYP1A2 P05177 1/20 0.45
▸ CYP2C19 P33261 1/20 0.45
▸ PKM P14618 1/20 0.44
▸ CYP19A1 P11511 1/20 0.44
▸ PTGER4 P35408 2/20 0.44
▸ NPSR1 Q6W5P4 2/20 0.44
▸ NSD2 O96028 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL975523 0.91 ALDH1A1 (0.44) ALDH1A1KDM4EMAPTMEN1KMT2A
SCHEMBL9776455 0.89 ALDH1A1 (0.55) ALDH1A1KDM4EMAPTMEN1KMT2A
SCHEMBL11142970 0.83 PGR (0.56) ALDH1A1KDM4ETDP1HPGDLMNA
SCHEMBL29360167 0.82 ALDH1A1 (0.75) ALDH1A1KDM4EMAPTMEN1KMT2A
SCHEMBL29963695 0.82 ALDH1A1 (0.75) ALDH1A1KDM4EMAPTMEN1KMT2A
SCHEMBL151563 0.82 ALDH1A1 (0.75) ALDH1A1KDM4EMAPTMEN1KMT2A
SCHEMBL14976913 0.82 PGR (0.51) KDM4EMAPTNPC1
SCHEMBL8697242 0.81 PSEN1 (0.52) KDM4EMAPT
SCHEMBL28517524 0.81 PSEN1 (0.52) KDM4EMAPT
SCHEMBL7977261 0.81 CYP19A1 (0.72) ALDH1A1KDM4EMAPTMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 206 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115232070-B Quinolinone alkaloid derivative containing acylhydrazone group on 1-position nitrogen atom, and preparation method and application thereof 太原理工大学 2023-06-30 — — CN claimed
CN-115974844-A 3,4,5-trimethoxyphenyl derivative and application thereof 广东省科学院动物研究所 2023-04-18 — — CN claimed
CN-113717209-A Synthesis method of alkyl silicon compound 南通大学 2021-11-30 — — CN claimed
CN-113462381-A Polar sensitive NIR probe with high binding force with amyloid fiber and preparation and application thereof 首都师范大学 2021-10-01 — — CN claimed
CN-113461706-A Fluorescent probe for rapidly identifying hydroxyl free radicals and preparation method and application thereof 首都师范大学 2021-10-01 — — CN claimed
EP-1836179-B1 PIPERIDINE- AND PIPERAZINE-1-CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF FATTY ACID AMIDE HYDROLASE (FAAH) FOR THE TREATMENT OF ANXIETY, PAIN AND OTHER CONDITIONS JANSSEN PHARMACEUTICA NV (BE) 2015-05-06 — — EP claimed
US-20140088029-A1 NOVEL PYRAZOLE DERIVATIVE PHARMA EIGHT CO., LTD. (JP) 2014-03-27 — — US claimed
EP-2698368-A1 NOVEL PYRAZOLE DERIVATIVE Pharma Eight Co. Ltd (JP) 2014-02-19 — — EP claimed
US-8530476-B2 Piperazinyl and piperidinyl ureas as modulators of fatty acid amide hydrolase JANSSEN PHARMACEUTICA NV (BE) 2013-09-10 — — US claimed
US-20100004261-A1 PIPERAZINYL AND PIPERIDINYL UREAS AS MODULATORS OF FATTY ACID AMIDE HYDROLASE JANSSEN PHARMACEUTICA NV (BE) 2010-01-07 — — US claimed
WO-1998034115-A1 4-SUBSTITUTED-QUINOLINE DERIVATIVES AND 4-SUBSTITUTE-QUINOLINE COMBINATORIAL LIBRARIES TREGA BIOSCIENCES, INC. (US) 1998-08-06 — — WO claimed
WO-1998034111-A1 TRICYCLIC TETRAHYDROQUINOLINE DERIVATIVES AND TRICYCLIC TETRAHYDROQUINOLINE COMBINATORIAL LIBRARIES TREGA BIOSCIENCES, INC. (US) 1998-08-06 — — WO claimed
WO-1997016428-A1 ISOQUINOLINE DERIVATIVES AND ISOQUINOLINE COMBINATORIAL LIBRARIES TORREY PINES INSTITUTE FOR MOLECULAR STUDIES (US) 1997-05-09 — — WO claimed
EP-0281012-B1 4-CHLORO-OXAZOLE DERIVATIVES, METHOD FOR THEIR PREPARATION AND THEIR USE HOECHST AKTIENGESELLSCHAFT (DE) 1991-12-11 — — EP claimed
US-4908447-A 2-,6-diphenylpyridine compounds useful as dye precursors BASF AKTIENGESELLSCHAFT (DE) 1990-03-13 — — US claimed
US-4892799-A PHOTOCONDUCTIVITY, ELECTROGRAPHY HOECHST AKTIENGESELLSCHAFT (DE) 1990-01-09 — — US claimed
EP-0261602-A2 Pyridine compounds and their use BASF Aktiengesellschaft (DE) 1988-03-30 — — EP claimed
US-4454211-A Electrophotographic photosensitive member with pyrazoline charge transport material CANON KABUSHIKI KAISHA (JP) 1984-06-12 — — US claimed
US-4132436-A Recording material FUJI PHOTO FILM CO., LTD. (JP) 1979-01-02 — — US claimed
US-4119777-A BY OXIDATION OF A THIOAMIDE DERIVATIVE FUJI PHOTO FILM CO., LTD. (JP) 1978-10-10 — — US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140088029-A1 NOVEL PYRAZOLE DERIVATIVE PSEN2, MAPT, PSEN1 ALDH1A1 675/4885KDM4E 3193/4885MAPT 2/4885
US-20100004261-A1 PIPERAZINYL AND PIPERIDINYL UREAS AS MODULATORS OF FATTY ACID AMIDE HYDROLASE FAAH, FAAH2, USP47 ALDH1A1 1437/4885KDM4E 704/4885MAPT 843/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.