SCHEMBL3348377

SCHEMBL3348377

Fc1cc2[nH]cc(CCNCC3CC3)c2cc1Cl

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR1A P08908 5/20 0.49
GPR84 Q9NQS5 2/20 0.49
MTNR1A P48039 3/20 0.46
MTNR1B P49286 2/20 0.46
MPO P05164 5/20 0.44
SLC6A4 P31645 2/20 0.44
HTR2B P41595 2/20 0.42
SNCA P37840 1/20 0.42
HTR6 P50406 1/20 0.41
MEN1 O00255 1/20 0.40
LMNA P02545 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2D6 P10635 1/20 0.40
CYP2C9 P11712 1/20 0.40
NFKB1 P19838 1/20 0.40
MAPK1 P28482 1/20 0.40
CYP2C19 P33261 1/20 0.40
THPO P40225 1/20 0.40
KMT2A Q03164 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2402869 0.90 GPR84 (0.51) HTR1AGPR84MTNR1AMTNR1BMPO
SCHEMBL3375922 0.80 MTNR1A (0.71) HTR1AGPR84MTNR1AMTNR1BSLC6A4
SCHEMBL2405163 0.80 GPR84 (0.54) HTR1AGPR84MTNR1AMTNR1BSLC6A4
SCHEMBL1969257 0.80 HTR6 (0.62) HTR1AGPR84MTNR1AMTNR1BMPO
SCHEMBL1970036 0.80 MPO (0.70) HTR1AMTNR1AMTNR1BMPOSLC6A4
SCHEMBL2409563 0.77 HTR1A (0.54) HTR1AMPOSLC6A4HTR2BSNCA
SCHEMBL25425428 0.75 GPR84 (0.63) HTR1AGPR84MPOHTR2BHTR6
SCHEMBL1971950 0.74 HTR2A (0.56) HTR1AMTNR1AMTNR1BHTR6MEN1
SCHEMBL2406261 0.74 MTNR1A (0.60) HTR1AGPR84MTNR1AMTNR1BMPO
SCHEMBL1976170 0.74 MTNR1A (0.61) HTR1AMTNR1AMTNR1BMPOSLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010044054-A1 PHENETHYLAMIDE DERIVATIVES AND THEIR HETEROCYCLIC ANALOGUES ACTELION PHARMACEUTICALS LTD (CH) 2010-04-22 WO claimed
WO-2010044054-A1 PHENETHYLAMIDE DERIVATIVES AND THEIR HETEROCYCLIC ANALOGUES ACTELION PHARMACEUTICALS LTD (CH) 2010-04-22 WO disclosed